Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance
Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Gene...
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5528 |
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| author | Michał Ciebiera Mohamed Ali Magdalena Zgliczyńska Maciej Skrzypczak Ayman Al-Hendy |
| author_facet | Michał Ciebiera Mohamed Ali Magdalena Zgliczyńska Maciej Skrzypczak Ayman Al-Hendy |
| author_sort | Michał Ciebiera |
| collection | DOAJ |
| description | Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Genetic studies have demonstrated that UFs are monoclonal tumors originating from the myometrial stem cells that have underwent specific molecular changes to tumor initiating stem cells which proliferate and differentiate later under the influence of steroid hormones. There is growing interest in the role of micronutrients, for example, vitamins, in UFs. This article is a comprehensive review of publications regarding the available data concerning the role of vitamins in the biology and management of UFs. In summary, the results showed that some vitamins are important in the biology and pathophysiology of UFs. For example, vitamins A and D deserve particular attention following studies of their influence on the treatment of UF tumors. Vitamins B3, C, and E have not been as widely studied as the abovementioned vitamins. However, more research could reveal their potential role in UF biology. |
| first_indexed | 2024-03-10T18:02:10Z |
| format | Article |
| id | doaj.art-656d81612ac9471ca04bacb791eb9b3c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:02:10Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-656d81612ac9471ca04bacb791eb9b3c2023-11-20T08:48:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012115552810.3390/ijms21155528Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical RelevanceMichał Ciebiera0Mohamed Ali1Magdalena Zgliczyńska2Maciej Skrzypczak3Ayman Al-Hendy4Second Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-809 Warsaw, PolandDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USASecond Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-809 Warsaw, PolandSecond Department of Gynecology, Medical University of Lublin, 20-954 Lublin, PolandDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USAUterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Genetic studies have demonstrated that UFs are monoclonal tumors originating from the myometrial stem cells that have underwent specific molecular changes to tumor initiating stem cells which proliferate and differentiate later under the influence of steroid hormones. There is growing interest in the role of micronutrients, for example, vitamins, in UFs. This article is a comprehensive review of publications regarding the available data concerning the role of vitamins in the biology and management of UFs. In summary, the results showed that some vitamins are important in the biology and pathophysiology of UFs. For example, vitamins A and D deserve particular attention following studies of their influence on the treatment of UF tumors. Vitamins B3, C, and E have not been as widely studied as the abovementioned vitamins. However, more research could reveal their potential role in UF biology.https://www.mdpi.com/1422-0067/21/15/5528uterine fibroidleiomyomapathophysiologyvitaminsvitamin Avitamin B3 |
| spellingShingle | Michał Ciebiera Mohamed Ali Magdalena Zgliczyńska Maciej Skrzypczak Ayman Al-Hendy Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance International Journal of Molecular Sciences uterine fibroid leiomyoma pathophysiology vitamins vitamin A vitamin B3 |
| title | Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance |
| title_full | Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance |
| title_fullStr | Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance |
| title_full_unstemmed | Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance |
| title_short | Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance |
| title_sort | vitamins and uterine fibroids current data on pathophysiology and possible clinical relevance |
| topic | uterine fibroid leiomyoma pathophysiology vitamins vitamin A vitamin B3 |
| url | https://www.mdpi.com/1422-0067/21/15/5528 |
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