Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12887 |
| _version_ | 1818991527436746752 |
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| author | Ippei Kikuchi Atsushi Takahashi-Kanemitsu Natsuki Sakiyama Chao Tang Pei-Jung Tang Saori Noda Kazuki Nakao Hidetoshi Kassai Toshiro Sato Atsu Aiba Masanori Hatakeyama |
| author_facet | Ippei Kikuchi Atsushi Takahashi-Kanemitsu Natsuki Sakiyama Chao Tang Pei-Jung Tang Saori Noda Kazuki Nakao Hidetoshi Kassai Toshiro Sato Atsu Aiba Masanori Hatakeyama |
| author_sort | Ippei Kikuchi |
| collection | DOAJ |
| description | Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis. |
| first_indexed | 2024-12-20T20:11:41Z |
| format | Article |
| id | doaj.art-656e488c9d224fa48eaa402ec5de0911 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:11:41Z |
| publishDate | 2016-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-656e488c9d224fa48eaa402ec5de09112022-12-21T19:27:49ZengNature PortfolioNature Communications2041-17232016-09-017111510.1038/ncomms12887Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathwaysIppei Kikuchi0Atsushi Takahashi-Kanemitsu1Natsuki Sakiyama2Chao Tang3Pei-Jung Tang4Saori Noda5Kazuki Nakao6Hidetoshi Kassai7Toshiro Sato8Atsu Aiba9Masanori Hatakeyama10Division of Microbiology, Graduate School of Medicine, The University of TokyoDivision of Microbiology, Graduate School of Medicine, The University of TokyoDivision of Microbiology, Graduate School of Medicine, The University of TokyoDivision of Microbiology, Graduate School of Medicine, The University of TokyoDivision of Microbiology, Graduate School of Medicine, The University of TokyoDivision of Microbiology, Graduate School of Medicine, The University of TokyoLaboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of TokyoLaboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of TokyoDivision of Gastroenterology, Keio University School of MedicineLaboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of TokyoDivision of Microbiology, Graduate School of Medicine, The University of TokyoNormal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis.https://doi.org/10.1038/ncomms12887 |
| spellingShingle | Ippei Kikuchi Atsushi Takahashi-Kanemitsu Natsuki Sakiyama Chao Tang Pei-Jung Tang Saori Noda Kazuki Nakao Hidetoshi Kassai Toshiro Sato Atsu Aiba Masanori Hatakeyama Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways Nature Communications |
| title | Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways |
| title_full | Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways |
| title_fullStr | Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways |
| title_full_unstemmed | Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways |
| title_short | Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways |
| title_sort | dephosphorylated parafibromin is a transcriptional coactivator of the wnt hedgehog notch pathways |
| url | https://doi.org/10.1038/ncomms12887 |
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