Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts

Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts

Abstract Patient-derived xenograft (PDX) tumor models are known to maintain the genomic and phenotypic profiles, including the histopathological structures, of the parental tumors. On the other hand, unique enrichment of single-nucleotide variants or copy number aberrations has been reported in seve...

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Bibliographic Details
Main Authors: Toshio Imai, Hiroshi Yoshida, Yukino Machida, Mizuki Kuramochi, Hitoshi Ichikawa, Takashi Kubo, Mami Takahashi, Tomoyasu Kato
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35703-6

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