Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics’ Treatment of Schizophrenia

Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics’ Treatment of Schizophrenia

Emerging evidence from genomics, post-mortem, and preclinical studies point to a potential dysregulation of molecular signaling at postsynaptic density (PSD) in schizophrenia pathophysiology. The PSD that identifies the archetypal asymmetric synapse is a structure of approximately 300 nm in diameter...

Full description

Bibliographic Details
Main Authors: Andrea de Bartolomeis, Licia Vellucci, Giuseppe De Simone, Benedetta Mazza, Annarita Barone, Mariateresa Ciccarelli
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
synaptic signaling
antipsychotics
postsynaptic density
treatment resistant schizophrenia
signalosome
connectome
Online Access:https://www.mdpi.com/2073-4409/12/4/574

Internet

https://www.mdpi.com/2073-4409/12/4/574

Similar Items