Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis
Neutrophil extracellular traps (NETs) are major contributors to inflammation and autoimmunity, playing a key role in the development of thrombotic disorders. NETs, composed of DNA, histones, and numerous other proteins serve as scaffolds for thrombus formation and promote platelet activation, coagul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/10/1332 |
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| author | José Perdomo Halina H. L. Leung |
| author_facet | José Perdomo Halina H. L. Leung |
| author_sort | José Perdomo |
| collection | DOAJ |
| description | Neutrophil extracellular traps (NETs) are major contributors to inflammation and autoimmunity, playing a key role in the development of thrombotic disorders. NETs, composed of DNA, histones, and numerous other proteins serve as scaffolds for thrombus formation and promote platelet activation, coagulation, and endothelial dysfunction. Accumulating evidence indicates that NETs mediate thrombosis in autoimmune diseases, viral and bacterial infections, cancer, and cardiovascular disease. This article reviews the role and mechanisms of immune complexes in NETs formation and their contribution to the generation of a prothrombotic state. Immune complexes are formed by interactions between antigens and antibodies and can induce NETosis by the direct activation of neutrophils via Fc receptors, via platelet activation, and through endothelial inflammation. We discuss the mechanisms by which NETs induced by immune complexes contribute to immune thrombotic processes and consider the potential development of therapeutic strategies. Targeting immune complexes and NETosis hold promise for mitigating thrombotic events and reducing the burden of immune thrombosis. |
| first_indexed | 2024-03-10T21:25:25Z |
| format | Article |
| id | doaj.art-6571a14d73e742eb8d3528f3bae3f00c |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T21:25:25Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-6571a14d73e742eb8d3528f3bae3f00c2023-11-19T15:43:49ZengMDPI AGBiology2079-77372023-10-011210133210.3390/biology12101332Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosisJosé Perdomo0Halina H. L. Leung1Haematology Research Group, Faculty Medicine and Health, Central Clinical School, University of Sydney, Sydney, NSW 2006, AustraliaHaematology Research Unit, St George & Sutherland Clinical Campuses, Faculty of Medicine & Health, School of Clinical Medicine, University of New South Wales, Kogarah, NSW 2217, AustraliaNeutrophil extracellular traps (NETs) are major contributors to inflammation and autoimmunity, playing a key role in the development of thrombotic disorders. NETs, composed of DNA, histones, and numerous other proteins serve as scaffolds for thrombus formation and promote platelet activation, coagulation, and endothelial dysfunction. Accumulating evidence indicates that NETs mediate thrombosis in autoimmune diseases, viral and bacterial infections, cancer, and cardiovascular disease. This article reviews the role and mechanisms of immune complexes in NETs formation and their contribution to the generation of a prothrombotic state. Immune complexes are formed by interactions between antigens and antibodies and can induce NETosis by the direct activation of neutrophils via Fc receptors, via platelet activation, and through endothelial inflammation. We discuss the mechanisms by which NETs induced by immune complexes contribute to immune thrombotic processes and consider the potential development of therapeutic strategies. Targeting immune complexes and NETosis hold promise for mitigating thrombotic events and reducing the burden of immune thrombosis.https://www.mdpi.com/2079-7737/12/10/1332immune thrombosisimmune complexneutrophil extracellular traps |
| spellingShingle | José Perdomo Halina H. L. Leung Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis Biology immune thrombosis immune complex neutrophil extracellular traps |
| title | Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis |
| title_full | Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis |
| title_fullStr | Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis |
| title_full_unstemmed | Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis |
| title_short | Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis |
| title_sort | immune thrombosis exploring the significance of immune complexes and netosis |
| topic | immune thrombosis immune complex neutrophil extracellular traps |
| url | https://www.mdpi.com/2079-7737/12/10/1332 |
| work_keys_str_mv | AT joseperdomo immunethrombosisexploringthesignificanceofimmunecomplexesandnetosis AT halinahlleung immunethrombosisexploringthesignificanceofimmunecomplexesandnetosis |