BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection

BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection

Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the excessive lipid peroxidation accumulation. However, whether targeting ferroptosis is an effective approach for SMC l...

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Bibliographic Details
Main Authors: Yue Chen, Xin Yi, Bo Huo, Yi He, Xian Guo, Zihao Zhang, Xiaoxuan Zhong, Xin Feng, Ze-Min Fang, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
Aortic dissection
Ferroptosis
BRD4770
Histone methylation
Inflammation
Smooth muscle cell
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000676

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