Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy

Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy

Abstract Objective Epilepsy can be comorbid with cognitive impairments. Recent evidence suggests the possibility that cognitive decline in epilepsy may be associated with mechanisms typical of Alzheimer's disease (AD). Neuropathological hallmarks of AD have been found in brain biopsies surgical...

Full description

Bibliographic Details
Main Authors:	Alisha Aroor, Phuoc Nguyen, Yibo Li, Rohit Das, Joaquin N. Lugo, Amy L. Brewster
Format:	Article
Language:	English
Published:	Wiley 2023-06-01
Series:	Epilepsia Open
Subjects:	Alzheimer's disease mTOR refractory epilepsy tau protein β‐amyloid
Online Access:	https://doi.org/10.1002/epi4.12744

Similar Items

A New Strategy in Epilepsy Therapy Through Attenuation of Phosphorylated Tau and Amyloid-beta
by: Junaidi Khotib, et al.
Published: (2025-03-01)

Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
by: Kaylin Hwang, et al.
Published: (2022-07-01)

Neurodegenerative pathways as targets for acquired epilepsy therapy development
by: Pablo M. Casillas‐Espinosa, et al.
Published: (2020-06-01)

Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
by: Niklas Mattsson‐Carlgren, et al.
Published: (2021-05-01)

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology
by: Noemi Esteras, et al.
Published: (2020-09-01)

SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers
by: Andrés Norambuena, et al.
Published: (2022-07-01)

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy
by: Wei Zhao, et al.
Published: (2023-06-01)

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
by: P. Hemachandra Reddy, et al.
Published: (2019-05-01)

Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology
by: Zsolt Huszár, et al.
Published: (2024-10-01)

Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
by: Erin R Cullen, et al.
Published: (2024-03-01)

Deletion of Murine APP Aggravates Tau and Amyloid Pathologies in the 5xFADXTg30 Alzheimer’s Disease Model
by: Kunie Ando, et al.
Published: (2025-01-01)

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
by: Evgenia Salta, et al.
Published: (2016-08-01)

Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer’s disease, and epilepsy
by: Samantha P. Martin, et al.
Published: (2024-01-01)

Expression of mTOR in normal and pathological conditions
by: A Marques-Ramos, et al.
Published: (2023-07-01)

Ventricular volume in relation to lumbar CSF levels of amyloid-β 1–42, tau and phosphorylated tau in iNPH, is there a dilution effect?
by: Simon Lidén, et al.
Published: (2022-07-01)

Understanding recent advances in non‐amyloid/non‐tau (NANT) biomarkers and therapeutic targets in Alzheimer's disease
by: Linda J. Van Eldik, et al.
Published: (2024-10-01)

Structure-based inhibitors of amyloid beta core suggest a common interface with tau
by: Sarah L Griner, et al.
Published: (2019-10-01)

Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients
by: Hyuk Sung Kwon, et al.
Published: (2025-03-01)

Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy
by: Hanxiao Zhu, et al.
Published: (2022-08-01)

Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target?
by: Castillo-Carranza DL, et al.
Published: (2013-12-01)

Moderation of thyroid hormones for the relationship between amyloid and tau pathology
by: Jeong Hyeon Byeon, et al.
Published: (2024-07-01)

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology
by: Taewon Kim, et al.
Published: (2022-12-01)

PICALM rs3851179 Variants Modulate Left Postcentral Cortex Thickness, CSF Amyloid β42, and Phosphorylated Tau in the Elderly
by: Zhiwei Wu, et al.
Published: (2022-12-01)

Performance of the Lumipulse plasma Aβ42/40 and pTau181 immunoassays in the detection of amyloid pathology
by: Daniel J. Figdore, et al.
Published: (2024-01-01)

Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)
by: Yuta Takaichi, et al.
Published: (2021-01-01)

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
by: Woo Shik Shin, et al.
Published: (2019-10-01)

Effect of mTOR Inhibitors in Epilepsy Treatment in Children with Tuberous Sclerosis Complex Under 2 Years of Age
by: Dominika Śmiałek, et al.
Published: (2023-04-01)

PTEN deletion in the adult dentate gyrus induces epilepsy
by: Jennifer M. Yonan, et al.
Published: (2024-12-01)

Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease
by: Yue Cai, et al.
Published: (2023-02-01)

Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis
by: Artur Sulik, et al.
Published: (2022-03-01)

Efficacy and safety of Everolimus in children with TSC - associated epilepsy – Pilot data from an open single-center prospective study
by: Sharon Samueli, et al.
Published: (2016-11-01)

Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer’s disease
by: Zhi-Bo Wang, et al.
Published: (2022-12-01)

Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model
by: Zhen-Dong Sun, et al.
Published: (2022-01-01)

Neurotrophin receptor p75 mediates amyloid β-induced tau pathology
by: Lin-Lin Shen, et al.
Published: (2019-12-01)

Mobility and associations with levels of cerebrospinal fluid amyloid β and tau in a memory clinic cohort
by: Gro Gujord Tangen, et al.
Published: (2023-02-01)

Trait Mindfulness Is Associated With Less Amyloid, Tau, and Cognitive Decline in Individuals at Risk for Alzheimer’s Disease
by: Cherie Strikwerda-Brown, et al.
Published: (2023-01-01)

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
by: Hee-Jeong Choi, et al.
Published: (2022-07-01)

Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
by: Alejandro R Roda, et al.
Published: (2022-01-01)

Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
by: Rory Boyle, et al.
Published: (2024-07-01)

Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals
by: Motonobu Fujishima, et al.
Published: (2024-04-01)