Regulatory T cells: balancing protection versus pathology
Foxp3+ regulatory T cells (Tregs) maintain immune tolerance, prevent autoimmunity and modulate immune responses during infection and cancer. Recent studies have revealed considerable heterogeneity and plasticity within the Treg compartment, depending on the immunological context, which may resu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2016-07-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/2211 |
| _version_ | 1811288986739539968 |
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| author | Nikolas Rakebrandt Katharina Littringer Nicole Joller |
| author_facet | Nikolas Rakebrandt Katharina Littringer Nicole Joller |
| author_sort | Nikolas Rakebrandt |
| collection | DOAJ |
| description |
Foxp3+ regulatory T cells (Tregs) maintain immune tolerance, prevent autoimmunity and modulate immune responses during infection and cancer. Recent studies have revealed considerable heterogeneity and plasticity within the Treg compartment, depending on the immunological context, which may result in Tregs losing their suppressive function in inflammatory environments. We review how dysfunctional Tregs contribute to disease pathogenesis in inflammatory conditions and how inappropriate regulatory responses may hamper protective immunity in the context of infection and cancer. We also discuss how Tregs might be targeted therapeutically to re-establish a proper balance between regulatory and effector responses in autoimmunity, infections, and cancer.
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| first_indexed | 2024-04-13T03:46:54Z |
| format | Article |
| id | doaj.art-65729c0dc2644433bb7c849ef6582f27 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-13T03:46:54Z |
| publishDate | 2016-07-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-65729c0dc2644433bb7c849ef6582f272022-12-22T03:04:00ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972016-07-01146313210.4414/smw.2016.14343Regulatory T cells: balancing protection versus pathologyNikolas RakebrandtKatharina LittringerNicole Joller Foxp3+ regulatory T cells (Tregs) maintain immune tolerance, prevent autoimmunity and modulate immune responses during infection and cancer. Recent studies have revealed considerable heterogeneity and plasticity within the Treg compartment, depending on the immunological context, which may result in Tregs losing their suppressive function in inflammatory environments. We review how dysfunctional Tregs contribute to disease pathogenesis in inflammatory conditions and how inappropriate regulatory responses may hamper protective immunity in the context of infection and cancer. We also discuss how Tregs might be targeted therapeutically to re-establish a proper balance between regulatory and effector responses in autoimmunity, infections, and cancer. https://www.smw.ch/index.php/smw/article/view/2211autoimmunityCancerinfectionsregulatory T cells |
| spellingShingle | Nikolas Rakebrandt Katharina Littringer Nicole Joller Regulatory T cells: balancing protection versus pathology Swiss Medical Weekly autoimmunity Cancer infections regulatory T cells |
| title | Regulatory T cells: balancing protection versus pathology |
| title_full | Regulatory T cells: balancing protection versus pathology |
| title_fullStr | Regulatory T cells: balancing protection versus pathology |
| title_full_unstemmed | Regulatory T cells: balancing protection versus pathology |
| title_short | Regulatory T cells: balancing protection versus pathology |
| title_sort | regulatory t cells balancing protection versus pathology |
| topic | autoimmunity Cancer infections regulatory T cells |
| url | https://www.smw.ch/index.php/smw/article/view/2211 |
| work_keys_str_mv | AT nikolasrakebrandt regulatorytcellsbalancingprotectionversuspathology AT katharinalittringer regulatorytcellsbalancingprotectionversuspathology AT nicolejoller regulatorytcellsbalancingprotectionversuspathology |