Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study
Biological control is an environmentally friendly and effective pest control strategy, but it is often affected by a variety of abiotic factors in the pest control area. Here, the susceptibility of gypsy moth larvae to Mamestra brassicae nuclear polyhedrosis virus (MbNPV) under Cd treatment at the l...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322001208 |
| _version_ | 1818297007127658496 |
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| author | Dun Jiang Mingtao Tan Lin Zheng Hongfei Wu Yaning Li Shanchun Yan |
| author_facet | Dun Jiang Mingtao Tan Lin Zheng Hongfei Wu Yaning Li Shanchun Yan |
| author_sort | Dun Jiang |
| collection | DOAJ |
| description | Biological control is an environmentally friendly and effective pest control strategy, but it is often affected by a variety of abiotic factors in the pest control area. Here, the susceptibility of gypsy moth larvae to Mamestra brassicae nuclear polyhedrosis virus (MbNPV) under Cd treatment at the low and high dosages was investigated, and the mechanism of Cd stress affecting virus susceptibility of gypsy moth larvae was analyzed from a metabolic perspective by combining transcriptome and metabolome of the larval fat body. Our results showed that the mortality of MBNPV infection on gypsy moth larvae pre-exposed to Cd was significantly higher than that of larvae without Cd pre-exposure, and the joint effects of Cd exposure and virus infection on larval mortality were demonstrated to be synergistic. Transcriptome analysis revealed that amino acid and carbohydrate transport and metabolism accounted for most of the differently expressed genes in the low Cd and high Cd treatment groups. Consistent with the transcriptome results, metabolome analysis also showed that most metabolites affected by Cd exposure were involved in amino acid and carbohydrate metabolism. Function analysis showed that the contents of several amino acids (e.g. tryptophan and tyrosine) with antioxidant properties were significantly increased in Cd-treated gypsy moth larvae. Taken together, Cd exposure as an environmental factor, promotes the susceptibility of gypsy moth larvae to MbNPV, and metabolic disruption, especially amino acids and carbohydrates-related metabolism, is responsible for the increased susceptibility of gypsy moth larvae to virus under Cd stress. |
| first_indexed | 2024-12-13T04:12:35Z |
| format | Article |
| id | doaj.art-65734192510b403991af00d8cc3ba3b6 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-13T04:12:35Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-65734192510b403991af00d8cc3ba3b62022-12-21T23:59:57ZengElsevierEcotoxicology and Environmental Safety0147-65132022-03-01232113280Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics studyDun Jiang0Mingtao Tan1Lin Zheng2Hongfei Wu3Yaning Li4Shanchun Yan5School of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, PR ChinaSchool of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, PR ChinaSchool of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, PR ChinaSchool of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, PR ChinaSchool of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, PR ChinaSchool of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; Corresponding author at: School of Forestry, Northeast Forestry University, Harbin 150040, PR China.Biological control is an environmentally friendly and effective pest control strategy, but it is often affected by a variety of abiotic factors in the pest control area. Here, the susceptibility of gypsy moth larvae to Mamestra brassicae nuclear polyhedrosis virus (MbNPV) under Cd treatment at the low and high dosages was investigated, and the mechanism of Cd stress affecting virus susceptibility of gypsy moth larvae was analyzed from a metabolic perspective by combining transcriptome and metabolome of the larval fat body. Our results showed that the mortality of MBNPV infection on gypsy moth larvae pre-exposed to Cd was significantly higher than that of larvae without Cd pre-exposure, and the joint effects of Cd exposure and virus infection on larval mortality were demonstrated to be synergistic. Transcriptome analysis revealed that amino acid and carbohydrate transport and metabolism accounted for most of the differently expressed genes in the low Cd and high Cd treatment groups. Consistent with the transcriptome results, metabolome analysis also showed that most metabolites affected by Cd exposure were involved in amino acid and carbohydrate metabolism. Function analysis showed that the contents of several amino acids (e.g. tryptophan and tyrosine) with antioxidant properties were significantly increased in Cd-treated gypsy moth larvae. Taken together, Cd exposure as an environmental factor, promotes the susceptibility of gypsy moth larvae to MbNPV, and metabolic disruption, especially amino acids and carbohydrates-related metabolism, is responsible for the increased susceptibility of gypsy moth larvae to virus under Cd stress.http://www.sciencedirect.com/science/article/pii/S0147651322001208Virus infectionMetabolic disruptionSynergisticBiocontrol efficiencyHeavy metal pollution |
| spellingShingle | Dun Jiang Mingtao Tan Lin Zheng Hongfei Wu Yaning Li Shanchun Yan Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study Ecotoxicology and Environmental Safety Virus infection Metabolic disruption Synergistic Biocontrol efficiency Heavy metal pollution |
| title | Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study |
| title_full | Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study |
| title_fullStr | Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study |
| title_full_unstemmed | Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study |
| title_short | Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study |
| title_sort | cd exposure triggered metabolic disruption increases the susceptibility of lymantria dispar lepidoptera erebidae larvae to mamestra brassicae nuclear polyhedrosis virus a multi omics study |
| topic | Virus infection Metabolic disruption Synergistic Biocontrol efficiency Heavy metal pollution |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322001208 |
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