Quantitative Proteome Profiling of Coxiella burnetii Reveals Major Metabolic and Stress Differences Under Axenic and Cell Culture Cultivation

Quantitative Proteome Profiling of Coxiella burnetii Reveals Major Metabolic and Stress Differences Under Axenic and Cell Culture Cultivation

Coxiella burnetii is the causative agent of the zoonotic disease Q fever. To date, the lipopolysaccharide (LPS) is the only defined and characterized virulence determinant of C. burnetii. In this study, proteome profiles of C. burnetii Nine Mile phase I (RSA 493, NMI) and its isogenic Nine Mile phas...

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Bibliographic Details
Main Authors: Jiri Dresler, Jana Klimentova, Petr Pajer, Barbora Salovska, Alena Myslivcova Fucikova, Martin Chmel, Gernot Schmoock, Heinrich Neubauer, Katja Mertens-Scholz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
Coxiella burnetii
axenic culture
semi-quantitative proteomics
oxidative stress response
type IV B secretion system
dot/icm
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02022/full

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