Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression?
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by continuous and selective degeneration or death of dopamine neurons in the midbrain, leading to dysfunction of the nigrostriatal neural circuits. Current clinical treatments for PD include drug treatment and surgery...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1210447/full |
| _version_ | 1827368404657373184 |
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| author | Yongkang Wu Xiangtian Meng Wai-Yin Cheng Wai-Yin Cheng Zhichao Yan Keqin Li Jian Wang Tianfang Jiang Fei Zhou Ka-Hing Wong Ka-Hing Wong Chunlong Zhong Yi Dong Shane Gao |
| author_facet | Yongkang Wu Xiangtian Meng Wai-Yin Cheng Wai-Yin Cheng Zhichao Yan Keqin Li Jian Wang Tianfang Jiang Fei Zhou Ka-Hing Wong Ka-Hing Wong Chunlong Zhong Yi Dong Shane Gao |
| author_sort | Yongkang Wu |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by continuous and selective degeneration or death of dopamine neurons in the midbrain, leading to dysfunction of the nigrostriatal neural circuits. Current clinical treatments for PD include drug treatment and surgery, which provide short-term relief of symptoms but are associated with many side effects and cannot reverse the progression of PD. Pluripotent/multipotent stem cells possess a self-renewal capacity and the potential to differentiate into dopaminergic neurons. Transplantation of pluripotent/multipotent stem cells or dopaminergic neurons derived from these cells is a promising strategy for the complete repair of damaged neural circuits in PD. This article reviews and summarizes the current preclinical/clinical treatments for PD, their efficacies, and the advantages/disadvantages of various stem cells, including pluripotent and multipotent stem cells, to provide a detailed overview of how these cells can be applied in the treatment of PD, as well as the challenges and bottlenecks that need to be overcome in future translational studies. |
| first_indexed | 2024-03-08T09:30:57Z |
| format | Article |
| id | doaj.art-6573cb6d01ed40aa92f231890072f468 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T09:30:57Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-6573cb6d01ed40aa92f231890072f4682024-01-31T04:30:14ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-01-011810.3389/fnins.2024.12104471210447Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression?Yongkang Wu0Xiangtian Meng1Wai-Yin Cheng2Wai-Yin Cheng3Zhichao Yan4Keqin Li5Jian Wang6Tianfang Jiang7Fei Zhou8Ka-Hing Wong9Ka-Hing Wong10Chunlong Zhong11Yi Dong12Shane Gao13Key Laboratory of Adolescent Health Evaluation and Sports Intervention, Ministry of Education, East China Normal University, Shanghai, ChinaDepartment of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaResearch Institute for Future Food, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaDepartment of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Neurology, Shanghai Eighth People’s Hospital Affiliated to Jiangsu University, Shanghai, ChinaDepartment of Neurology, Third Affiliated Hospital of Navy Military Medical University, Shanghai, ChinaResearch Institute for Future Food, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, ChinaDepartment of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaKey Laboratory of Adolescent Health Evaluation and Sports Intervention, Ministry of Education, East China Normal University, Shanghai, ChinaDepartment of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by continuous and selective degeneration or death of dopamine neurons in the midbrain, leading to dysfunction of the nigrostriatal neural circuits. Current clinical treatments for PD include drug treatment and surgery, which provide short-term relief of symptoms but are associated with many side effects and cannot reverse the progression of PD. Pluripotent/multipotent stem cells possess a self-renewal capacity and the potential to differentiate into dopaminergic neurons. Transplantation of pluripotent/multipotent stem cells or dopaminergic neurons derived from these cells is a promising strategy for the complete repair of damaged neural circuits in PD. This article reviews and summarizes the current preclinical/clinical treatments for PD, their efficacies, and the advantages/disadvantages of various stem cells, including pluripotent and multipotent stem cells, to provide a detailed overview of how these cells can be applied in the treatment of PD, as well as the challenges and bottlenecks that need to be overcome in future translational studies.https://www.frontiersin.org/articles/10.3389/fnins.2024.1210447/fullpluripotent stem cellsmultipotent stem cellsParkinson’s diseasedopaminetransplantation |
| spellingShingle | Yongkang Wu Xiangtian Meng Wai-Yin Cheng Wai-Yin Cheng Zhichao Yan Keqin Li Jian Wang Tianfang Jiang Fei Zhou Ka-Hing Wong Ka-Hing Wong Chunlong Zhong Yi Dong Shane Gao Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression? Frontiers in Neuroscience pluripotent stem cells multipotent stem cells Parkinson’s disease dopamine transplantation |
| title | Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression? |
| title_full | Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression? |
| title_fullStr | Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression? |
| title_full_unstemmed | Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression? |
| title_short | Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression? |
| title_sort | can pluripotent multipotent stem cells reverse parkinson s disease progression |
| topic | pluripotent stem cells multipotent stem cells Parkinson’s disease dopamine transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1210447/full |
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