In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue
Mutations in mitochondrial DNA can lead to clinically heterogeneous disease. Here the authors demonstrate in vivo base editing of mouse mitochondrial DNA in a post-mitotic tissue by AAV delivery of DddA-derived cytosine base editor (DdCBE).
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28358-w |
| _version_ | 1818977102460878848 |
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| author | Pedro Silva-Pinheiro Pavel A. Nash Lindsey Van Haute Christian D. Mutti Keira Turner Michal Minczuk |
| author_facet | Pedro Silva-Pinheiro Pavel A. Nash Lindsey Van Haute Christian D. Mutti Keira Turner Michal Minczuk |
| author_sort | Pedro Silva-Pinheiro |
| collection | DOAJ |
| description | Mutations in mitochondrial DNA can lead to clinically heterogeneous disease. Here the authors demonstrate in vivo base editing of mouse mitochondrial DNA in a post-mitotic tissue by AAV delivery of DddA-derived cytosine base editor (DdCBE). |
| first_indexed | 2024-12-20T16:22:24Z |
| format | Article |
| id | doaj.art-6575427a5bcd453285e13ddba4173df3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:22:24Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6575427a5bcd453285e13ddba4173df32022-12-21T19:33:34ZengNature PortfolioNature Communications2041-17232022-02-011311910.1038/s41467-022-28358-wIn vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissuePedro Silva-Pinheiro0Pavel A. Nash1Lindsey Van Haute2Christian D. Mutti3Keira Turner4Michal Minczuk5MRC Mitochondrial Biology Unit, University of CambridgeMRC Mitochondrial Biology Unit, University of CambridgeMRC Mitochondrial Biology Unit, University of CambridgeMRC Mitochondrial Biology Unit, University of CambridgeMRC Mitochondrial Biology Unit, University of CambridgeMRC Mitochondrial Biology Unit, University of CambridgeMutations in mitochondrial DNA can lead to clinically heterogeneous disease. Here the authors demonstrate in vivo base editing of mouse mitochondrial DNA in a post-mitotic tissue by AAV delivery of DddA-derived cytosine base editor (DdCBE).https://doi.org/10.1038/s41467-022-28358-w |
| spellingShingle | Pedro Silva-Pinheiro Pavel A. Nash Lindsey Van Haute Christian D. Mutti Keira Turner Michal Minczuk In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue Nature Communications |
| title | In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue |
| title_full | In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue |
| title_fullStr | In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue |
| title_full_unstemmed | In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue |
| title_short | In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue |
| title_sort | in vivo mitochondrial base editing via adeno associated viral delivery to mouse post mitotic tissue |
| url | https://doi.org/10.1038/s41467-022-28358-w |
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