Aptamer‐based extracellular vesicle isolation, analysis and therapeutics
Abstract Extracellular vesicles (EVs) play an important role in many physiological processes. Thus, EV analysis has a great value for the understanding of mechanisms underlying disease progress or diagnosis, prognosis and therapy. The overlapped physical and immune properties between EVs and events...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-04-01
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| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20220019 |
| _version_ | 1797772454394855424 |
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| author | Lin Zhu Wenhai Tian Lijie Yuan Caixing Chi Yulin Wang Qiaoling Xiao Meiyu Zheng Chaoyong Yang Yanling Song |
| author_facet | Lin Zhu Wenhai Tian Lijie Yuan Caixing Chi Yulin Wang Qiaoling Xiao Meiyu Zheng Chaoyong Yang Yanling Song |
| author_sort | Lin Zhu |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) play an important role in many physiological processes. Thus, EV analysis has a great value for the understanding of mechanisms underlying disease progress or diagnosis, prognosis and therapy. The overlapped physical and immune properties between EVs and events in body fluids, as well as the phenotypic heterogeneity of EVs, require efficient isolation and analysis methods. The unique properties of aptamers, such as facile modification and programmability, make them easily assembled as powerful platforms for EV isolation and analysis. EVs can also be used as vehicles for drug delivery, benefiting from the properties of homing ability, hypo‐immunogenicity, and strong tolerance. The affinity recognition ability to targets and the feature of single stranded DNA of aptamers make them useful in promoting the targetability of EVs and delivery of nucleic acid drugs. This review summarizes recent progress in aptamer‐based EV isolation, analysis, and aptamer‐functionalized EVs for therapeutics. |
| first_indexed | 2024-03-12T21:52:11Z |
| format | Article |
| id | doaj.art-657682ac096945979ed6635696549fca |
| institution | Directory Open Access Journal |
| issn | 2832-6245 |
| language | English |
| last_indexed | 2024-03-12T21:52:11Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj.art-657682ac096945979ed6635696549fca2023-07-26T01:35:59ZengWiley-VCHInterdisciplinary Medicine2832-62452023-04-0112n/an/a10.1002/INMD.20220019Aptamer‐based extracellular vesicle isolation, analysis and therapeuticsLin Zhu0Wenhai Tian1Lijie Yuan2Caixing Chi3Yulin Wang4Qiaoling Xiao5Meiyu Zheng6Chaoyong Yang7Yanling Song8The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian ChinaThe MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian ChinaSpeciality of Medical Laboratory Science, Department of Basic Medical Science Xiamen Medical College Xiamen Fujian ChinaSpeciality of Medical Laboratory Science, Department of Basic Medical Science Xiamen Medical College Xiamen Fujian ChinaSpeciality of Medical Laboratory Science, Department of Basic Medical Science Xiamen Medical College Xiamen Fujian ChinaSpeciality of Medical Laboratory Science, Department of Basic Medical Science Xiamen Medical College Xiamen Fujian ChinaSpeciality of Medical Laboratory Science, Department of Basic Medical Science Xiamen Medical College Xiamen Fujian ChinaThe MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian ChinaThe MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian ChinaAbstract Extracellular vesicles (EVs) play an important role in many physiological processes. Thus, EV analysis has a great value for the understanding of mechanisms underlying disease progress or diagnosis, prognosis and therapy. The overlapped physical and immune properties between EVs and events in body fluids, as well as the phenotypic heterogeneity of EVs, require efficient isolation and analysis methods. The unique properties of aptamers, such as facile modification and programmability, make them easily assembled as powerful platforms for EV isolation and analysis. EVs can also be used as vehicles for drug delivery, benefiting from the properties of homing ability, hypo‐immunogenicity, and strong tolerance. The affinity recognition ability to targets and the feature of single stranded DNA of aptamers make them useful in promoting the targetability of EVs and delivery of nucleic acid drugs. This review summarizes recent progress in aptamer‐based EV isolation, analysis, and aptamer‐functionalized EVs for therapeutics.https://doi.org/10.1002/INMD.20220019aptamerdrug deliveryextracellular vesiclesextracellular vesicle detectionextracellular vesicle isolation |
| spellingShingle | Lin Zhu Wenhai Tian Lijie Yuan Caixing Chi Yulin Wang Qiaoling Xiao Meiyu Zheng Chaoyong Yang Yanling Song Aptamer‐based extracellular vesicle isolation, analysis and therapeutics Interdisciplinary Medicine aptamer drug delivery extracellular vesicles extracellular vesicle detection extracellular vesicle isolation |
| title | Aptamer‐based extracellular vesicle isolation, analysis and therapeutics |
| title_full | Aptamer‐based extracellular vesicle isolation, analysis and therapeutics |
| title_fullStr | Aptamer‐based extracellular vesicle isolation, analysis and therapeutics |
| title_full_unstemmed | Aptamer‐based extracellular vesicle isolation, analysis and therapeutics |
| title_short | Aptamer‐based extracellular vesicle isolation, analysis and therapeutics |
| title_sort | aptamer based extracellular vesicle isolation analysis and therapeutics |
| topic | aptamer drug delivery extracellular vesicles extracellular vesicle detection extracellular vesicle isolation |
| url | https://doi.org/10.1002/INMD.20220019 |
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