Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/11/3083 |
| _version_ | 1797531310894350336 |
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| author | Cristiana Maria Grapa Lucian Mocan Dana Crisan Mira Florea Teodora Mocan |
| author_facet | Cristiana Maria Grapa Lucian Mocan Dana Crisan Mira Florea Teodora Mocan |
| author_sort | Cristiana Maria Grapa |
| collection | DOAJ |
| description | As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved method for early detection, extended asymptomatic state, limited treatment options, poor chemotherapy response and dense tumor stroma that impedes drug delivery. We provide a narrative review of our main findings in the field of nanoparticle directed treatment for PC, with a focus on biomarker targeted delivery. By reducing drug toxicity, increasing their tumor accumulation, ability to modulate tumor microenvironment and even improve imaging contrast, it seems that nanotechnology may one day give hope for better outcome in pancreatic cancer. Further conjugating nanoparticles with biomarkers that are overexpressed amplifies the benefits mentioned, with potential increase in survival and treatment response. |
| first_indexed | 2024-03-10T10:41:58Z |
| format | Article |
| id | doaj.art-65775d771f8b49a9a746352d4e45af1b |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T10:41:58Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-65775d771f8b49a9a746352d4e45af1b2023-11-21T22:51:34ZengMDPI AGMaterials1996-19442021-06-011411308310.3390/ma14113083Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and TherapyCristiana Maria Grapa0Lucian Mocan1Dana Crisan2Mira Florea3Teodora Mocan4Physiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaNanomedicine Department, Regional Institute of Gastroenterology and Hepatology, 400126 Cluj-Napoca, RomaniaInternal Medicine Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaFamily Medicine Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaPhysiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaAs the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved method for early detection, extended asymptomatic state, limited treatment options, poor chemotherapy response and dense tumor stroma that impedes drug delivery. We provide a narrative review of our main findings in the field of nanoparticle directed treatment for PC, with a focus on biomarker targeted delivery. By reducing drug toxicity, increasing their tumor accumulation, ability to modulate tumor microenvironment and even improve imaging contrast, it seems that nanotechnology may one day give hope for better outcome in pancreatic cancer. Further conjugating nanoparticles with biomarkers that are overexpressed amplifies the benefits mentioned, with potential increase in survival and treatment response.https://www.mdpi.com/1996-1944/14/11/3083biomarkersnanoparticlespancreatic cancertargeted therapy |
| spellingShingle | Cristiana Maria Grapa Lucian Mocan Dana Crisan Mira Florea Teodora Mocan Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy Materials biomarkers nanoparticles pancreatic cancer targeted therapy |
| title | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
| title_full | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
| title_fullStr | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
| title_full_unstemmed | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
| title_short | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
| title_sort | biomarkers in pancreatic cancer as analytic targets for nanomediated imaging and therapy |
| topic | biomarkers nanoparticles pancreatic cancer targeted therapy |
| url | https://www.mdpi.com/1996-1944/14/11/3083 |
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