Molecular Mechanism of the Cell Death Induced by the Histone Deacetylase Pan Inhibitor LBH589 (Panobinostat) in Wilms Tumor Cells.

Molecular Mechanism of the Cell Death Induced by the Histone Deacetylase Pan Inhibitor LBH589 (Panobinostat) in Wilms Tumor Cells.

Wilms tumor (WT) is an embryonic kidney cancer, for which histone acetylation might be a therapeutic target. LBH589, a novel targeted agent, suppresses histone deacetylases in many tumors. This study investigated the antitumor activity of LBH589 in SK-NEP-1 and G401 cells.SK-NEP-1 and G401 cell grow...

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Bibliographic Details
Main Authors: Tao Yan-Fang, Li Zhi-Heng, Xu Li-Xiao, Fang Fang, Lu Jun, Li Gang, Cao Lan, Wang Na-Na, Du Xiao-Juan, Sun Li-Chao, Zhao Wen-Li, Xiao Pei-Fang, Zhao He, Su Guang-Hao, Li Yan-Hong, Li Yi-Ping, Xu Yun-Yun, Zhou Hui-Ting, Wu Yi, Jin Mei-Fang, Liu Lin, Ni Jian, Hu Shao-Yan, Zhu Xue-Ming, Feng Xing, Wang Jian, Pan Jian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503685?pdf=render

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