Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes
Aim:This study is conducted to examine the correlation between vitamin D deficiency and type 1 diabetes since diabetes incidence is rising and recent studies have revealed extra osseous effects of vitamin D.Materials and Methods:Eighty patients with newly diagnosed type 1 diabetes and 30 patients wi...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2022-12-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/vitamin-d-status-and-ts-relationship-with-clinical/57546
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| _version_ | 1797918898679447552 |
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| author | Ajda MUTLU MIHÇIOĞLU Şükrü HATUN |
| author_facet | Ajda MUTLU MIHÇIOĞLU Şükrü HATUN |
| author_sort | Ajda MUTLU MIHÇIOĞLU |
| collection | DOAJ |
| description | Aim:This study is conducted to examine the correlation between vitamin D deficiency and type 1 diabetes since diabetes incidence is rising and recent studies have revealed extra osseous effects of vitamin D.Materials and Methods:Eighty patients with newly diagnosed type 1 diabetes and 30 patients with no systemic disease were included in the study. Serum 25-hydroxyvitamin D (25-OHD), parathormone (PTH), calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) samples were obtained from both groups. Blood gas parameters were also obtained from the diabetic group. Information concerning vitamin D usage during pregnancy and infancy was acquired through personal interviews with patient’s mothers.Results:25-OHD levels were lower in the diabetic group than in the controls (24.43±16.25 ng/mL vs. 34.55±15.03 ng/mL, respectively, p=0.001), but the difference was not significant when seasonal variation was taken into consideration (33.44±17.23 ng/mL, vs. 34.55±15.03 ng/mL, p>0.05). Vitamin D levels were similar between the groups with ketoacidosis and non-acidotic group, p>0.05, for all). Ca, P, ALP and PTH levels were also similar at the time of diagnosis in the acidotic and non-acidotic groups (p>0.05, for all). The relationship between vitamin D use during pregnancy and infancy and the development of type 1 diabetes was similar between the diabetic and control groups (p>0.05).Conclusion:No significant effects of vitamin D deficiency/insufficiency on the development of diabetes and clinical status at admission was detected. Vitamin D intake in infancy and pregnancy exhibited no protective effect against the progression of diabetes. Therefore, it does not seem possible to reach a definitive conclusion about the relationship of vitamin D and type 1 diabetes. |
| first_indexed | 2024-04-10T13:36:45Z |
| format | Article |
| id | doaj.art-6577e43d273e424389a56720eb6b3d31 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T13:36:45Z |
| publishDate | 2022-12-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-6577e43d273e424389a56720eb6b3d312023-02-15T16:11:21ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622022-12-0110441842410.4274/nkmj.galenos.2022.9870013049054Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 DiabetesAjda MUTLU MIHÇIOĞLU0Şükrü HATUN1 Sağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, İstanbul, Türkiye Koç University Faculty of Medicine, Department of Pediatrics, Clinic of Pediatric Endocrinology and Metabolism, İstanbul, Turkey Aim:This study is conducted to examine the correlation between vitamin D deficiency and type 1 diabetes since diabetes incidence is rising and recent studies have revealed extra osseous effects of vitamin D.Materials and Methods:Eighty patients with newly diagnosed type 1 diabetes and 30 patients with no systemic disease were included in the study. Serum 25-hydroxyvitamin D (25-OHD), parathormone (PTH), calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) samples were obtained from both groups. Blood gas parameters were also obtained from the diabetic group. Information concerning vitamin D usage during pregnancy and infancy was acquired through personal interviews with patient’s mothers.Results:25-OHD levels were lower in the diabetic group than in the controls (24.43±16.25 ng/mL vs. 34.55±15.03 ng/mL, respectively, p=0.001), but the difference was not significant when seasonal variation was taken into consideration (33.44±17.23 ng/mL, vs. 34.55±15.03 ng/mL, p>0.05). Vitamin D levels were similar between the groups with ketoacidosis and non-acidotic group, p>0.05, for all). Ca, P, ALP and PTH levels were also similar at the time of diagnosis in the acidotic and non-acidotic groups (p>0.05, for all). The relationship between vitamin D use during pregnancy and infancy and the development of type 1 diabetes was similar between the diabetic and control groups (p>0.05).Conclusion:No significant effects of vitamin D deficiency/insufficiency on the development of diabetes and clinical status at admission was detected. Vitamin D intake in infancy and pregnancy exhibited no protective effect against the progression of diabetes. Therefore, it does not seem possible to reach a definitive conclusion about the relationship of vitamin D and type 1 diabetes. http://namikkemalmedj.com/archives/archive-detail/article-preview/vitamin-d-status-and-ts-relationship-with-clinical/57546 type 1 diabetesdiabetic ketoacidosisvitamin d |
| spellingShingle | Ajda MUTLU MIHÇIOĞLU Şükrü HATUN Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes Namık Kemal Tıp Dergisi type 1 diabetes diabetic ketoacidosis vitamin d |
| title | Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes |
| title_full | Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes |
| title_fullStr | Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes |
| title_full_unstemmed | Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes |
| title_short | Vitamin D Status and Its Relationship with Clinical Presentation Characteristics in Children with the Diagnosis of Type 1 Diabetes |
| title_sort | vitamin d status and its relationship with clinical presentation characteristics in children with the diagnosis of type 1 diabetes |
| topic | type 1 diabetes diabetic ketoacidosis vitamin d |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/vitamin-d-status-and-ts-relationship-with-clinical/57546
|
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