Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation
Objective We aimed to evaluate the effect of prolonged recovery from DGF on outcomes, using a new definition of DGF recovery time, among deceased donor kidney transplant recipients with DGF, and to examine the risk factors for prolonged recovery. Methods From 2007 to 2016, 91 deceased donor kidney t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2020.1803084 |
| _version_ | 1818615107639312384 |
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| author | Huanxi Zhang Qian Fu Jinqi Liu Jun Li Ronghai Deng Chenglin Wu Weijian Nie Xutao Chen Longshan Liu Changxi Wang |
| author_facet | Huanxi Zhang Qian Fu Jinqi Liu Jun Li Ronghai Deng Chenglin Wu Weijian Nie Xutao Chen Longshan Liu Changxi Wang |
| author_sort | Huanxi Zhang |
| collection | DOAJ |
| description | Objective We aimed to evaluate the effect of prolonged recovery from DGF on outcomes, using a new definition of DGF recovery time, among deceased donor kidney transplant recipients with DGF, and to examine the risk factors for prolonged recovery. Methods From 2007 to 2016, 91 deceased donor kidney transplant recipients with DGF were retrospectively analyzed. DGF recovery time was defined as the time from transplantation to achieve a stable estimated glomerular filtration rate (eGFR). Recipients with a DGF recovery time greater than or equal to the median were assigned to the prolonged recovery group, while the others were assigned to the rapid recovery group. Result The median DGF recovery time was 27 days. Donor terminal eGFR was significantly lower in the prolonged recovery group (n = 46) compared with the rapid recovery group (n = 45) (median 24.9 vs. 65.4 ml/min/1.73m2, p = 0.004). The eGFR at 1 year post-transplant in the prolonged recovery group was significantly lower than that in the rapid recovery group (50.6 ± 20.0 vs. 63.5 ± 21.4 ml/min/1.73m2, p = 0.005). The risk of adverse outcomes (acute rejection, pneumonia, graft failure, and death) was significantly greater in the prolonged recovery group (hazard ratio 2.604, 95% confidence interval 1.102–6.150, p = 0.029) compared with the rapid recovery group. Conclusion Decreased donor terminal eGFR is a risk factor for prolonged recovery from DGF after deceased kidney transplantation. Prolonged DGF recovery time is associated with reduced graft function at 1-year post-transplant, and poor transplant outcome. |
| first_indexed | 2024-12-16T16:28:39Z |
| format | Article |
| id | doaj.art-6578252b852241a3bcfc6fb7a43b3676 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-16T16:28:39Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-6578252b852241a3bcfc6fb7a43b36762022-12-21T22:24:40ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492020-01-0142179279810.1080/0886022X.2020.18030841803084Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantationHuanxi Zhang0Qian Fu1Jinqi Liu2Jun Li3Ronghai Deng4Chenglin Wu5Weijian Nie6Xutao Chen7Longshan Liu8Changxi Wang9Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityZhongshan School of Medicine, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen UniversityObjective We aimed to evaluate the effect of prolonged recovery from DGF on outcomes, using a new definition of DGF recovery time, among deceased donor kidney transplant recipients with DGF, and to examine the risk factors for prolonged recovery. Methods From 2007 to 2016, 91 deceased donor kidney transplant recipients with DGF were retrospectively analyzed. DGF recovery time was defined as the time from transplantation to achieve a stable estimated glomerular filtration rate (eGFR). Recipients with a DGF recovery time greater than or equal to the median were assigned to the prolonged recovery group, while the others were assigned to the rapid recovery group. Result The median DGF recovery time was 27 days. Donor terminal eGFR was significantly lower in the prolonged recovery group (n = 46) compared with the rapid recovery group (n = 45) (median 24.9 vs. 65.4 ml/min/1.73m2, p = 0.004). The eGFR at 1 year post-transplant in the prolonged recovery group was significantly lower than that in the rapid recovery group (50.6 ± 20.0 vs. 63.5 ± 21.4 ml/min/1.73m2, p = 0.005). The risk of adverse outcomes (acute rejection, pneumonia, graft failure, and death) was significantly greater in the prolonged recovery group (hazard ratio 2.604, 95% confidence interval 1.102–6.150, p = 0.029) compared with the rapid recovery group. Conclusion Decreased donor terminal eGFR is a risk factor for prolonged recovery from DGF after deceased kidney transplantation. Prolonged DGF recovery time is associated with reduced graft function at 1-year post-transplant, and poor transplant outcome.http://dx.doi.org/10.1080/0886022X.2020.1803084kidney transplantationdelayed graft functionacute kidney injurygraft survival |
| spellingShingle | Huanxi Zhang Qian Fu Jinqi Liu Jun Li Ronghai Deng Chenglin Wu Weijian Nie Xutao Chen Longshan Liu Changxi Wang Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation Renal Failure kidney transplantation delayed graft function acute kidney injury graft survival |
| title | Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation |
| title_full | Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation |
| title_fullStr | Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation |
| title_full_unstemmed | Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation |
| title_short | Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation |
| title_sort | risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation |
| topic | kidney transplantation delayed graft function acute kidney injury graft survival |
| url | http://dx.doi.org/10.1080/0886022X.2020.1803084 |
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