Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity
Abstract Background Previous studies have demonstrated that strabismus amblyopia can result in markedly brain function alterations. However, the differences in spontaneous brain activities of strabismus amblyopia (SA) patients still remain unclear. Therefore, the current study intended to employthe...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-06-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-021-02015-0 |
| _version_ | 1818741451288215552 |
|---|---|
| author | Shuang Zhang Gui-Ping Gao Wen-Qing Shi Biao Li Qi Lin Hui-Ye Shu Yi Shao |
| author_facet | Shuang Zhang Gui-Ping Gao Wen-Qing Shi Biao Li Qi Lin Hui-Ye Shu Yi Shao |
| author_sort | Shuang Zhang |
| collection | DOAJ |
| description | Abstract Background Previous studies have demonstrated that strabismus amblyopia can result in markedly brain function alterations. However, the differences in spontaneous brain activities of strabismus amblyopia (SA) patients still remain unclear. Therefore, the current study intended to employthe voxel-mirrored homotopic connectivity (VMHC) method to investigate the intrinsic brain activity changes in SA patients. Purpose To investigate the changes in cerebral hemispheric functional connections in patients with SA and their relationship with clinical manifestations using the VMHC method. Material and methods In the present study, a total of 17 patients with SA (eight males and nine females) and 17 age- and weight-matched healthy control (HC) groups were enrolled. Based on the VMHC method, all subjects were examined by functional magnetic resonance imaging. The functional interaction between cerebral hemispheres was directly evaluated. The Pearson’s correlation test was used to analyze the clinical features of patients with SA. In addition, their mean VMHC signal values and the receiver operating characteristic curve were used to distinguish patients with SA and HC groups. Results Compared with HC group, patients with SA had higher VMHC values in bilateral cingulum ant, caudate, hippocampus, and cerebellum crus 1. Moreover, the VMHC values of some regions were positively correlated with some clinical manifestations. In addition, receiver operating characteristic curves presented higher diagnostic value in these areas. Conclusion SA subjects showed abnormal brain interhemispheric functional connectivity in visual pathways, which might give some instructive information for understanding the neurological mechanisms of SA patients. |
| first_indexed | 2024-12-18T01:56:50Z |
| format | Article |
| id | doaj.art-657922b7d7da4aa9a3e1fffe1ce39c14 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-18T01:56:50Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-657922b7d7da4aa9a3e1fffe1ce39c142022-12-21T21:24:54ZengBMCBMC Ophthalmology1471-24152021-06-0121111010.1186/s12886-021-02015-0Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivityShuang Zhang0Gui-Ping Gao1Wen-Qing Shi2Biao Li3Qi Lin4Hui-Ye Shu5Yi Shao6Department of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityAbstract Background Previous studies have demonstrated that strabismus amblyopia can result in markedly brain function alterations. However, the differences in spontaneous brain activities of strabismus amblyopia (SA) patients still remain unclear. Therefore, the current study intended to employthe voxel-mirrored homotopic connectivity (VMHC) method to investigate the intrinsic brain activity changes in SA patients. Purpose To investigate the changes in cerebral hemispheric functional connections in patients with SA and their relationship with clinical manifestations using the VMHC method. Material and methods In the present study, a total of 17 patients with SA (eight males and nine females) and 17 age- and weight-matched healthy control (HC) groups were enrolled. Based on the VMHC method, all subjects were examined by functional magnetic resonance imaging. The functional interaction between cerebral hemispheres was directly evaluated. The Pearson’s correlation test was used to analyze the clinical features of patients with SA. In addition, their mean VMHC signal values and the receiver operating characteristic curve were used to distinguish patients with SA and HC groups. Results Compared with HC group, patients with SA had higher VMHC values in bilateral cingulum ant, caudate, hippocampus, and cerebellum crus 1. Moreover, the VMHC values of some regions were positively correlated with some clinical manifestations. In addition, receiver operating characteristic curves presented higher diagnostic value in these areas. Conclusion SA subjects showed abnormal brain interhemispheric functional connectivity in visual pathways, which might give some instructive information for understanding the neurological mechanisms of SA patients.https://doi.org/10.1186/s12886-021-02015-0Strabismic amblyopiafMRIVMHCFunctional connectivity |
| spellingShingle | Shuang Zhang Gui-Ping Gao Wen-Qing Shi Biao Li Qi Lin Hui-Ye Shu Yi Shao Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity BMC Ophthalmology Strabismic amblyopia fMRI VMHC Functional connectivity |
| title | Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity |
| title_full | Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity |
| title_fullStr | Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity |
| title_full_unstemmed | Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity |
| title_short | Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity |
| title_sort | abnormal interhemispheric functional connectivity in patients with strabismic amblyopia a resting state fmri study using voxel mirrored homotopic connectivity |
| topic | Strabismic amblyopia fMRI VMHC Functional connectivity |
| url | https://doi.org/10.1186/s12886-021-02015-0 |
| work_keys_str_mv | AT shuangzhang abnormalinterhemisphericfunctionalconnectivityinpatientswithstrabismicamblyopiaarestingstatefmristudyusingvoxelmirroredhomotopicconnectivity AT guipinggao abnormalinterhemisphericfunctionalconnectivityinpatientswithstrabismicamblyopiaarestingstatefmristudyusingvoxelmirroredhomotopicconnectivity AT wenqingshi abnormalinterhemisphericfunctionalconnectivityinpatientswithstrabismicamblyopiaarestingstatefmristudyusingvoxelmirroredhomotopicconnectivity AT biaoli abnormalinterhemisphericfunctionalconnectivityinpatientswithstrabismicamblyopiaarestingstatefmristudyusingvoxelmirroredhomotopicconnectivity AT qilin abnormalinterhemisphericfunctionalconnectivityinpatientswithstrabismicamblyopiaarestingstatefmristudyusingvoxelmirroredhomotopicconnectivity AT huiyeshu abnormalinterhemisphericfunctionalconnectivityinpatientswithstrabismicamblyopiaarestingstatefmristudyusingvoxelmirroredhomotopicconnectivity AT yishao abnormalinterhemisphericfunctionalconnectivityinpatientswithstrabismicamblyopiaarestingstatefmristudyusingvoxelmirroredhomotopicconnectivity |