Linking cortex and contraction—Integrating models along the corticomuscular pathway
Computational models of the neuromusculoskeletal system provide a deterministic approach to investigate input-output relationships in the human motor system. Neuromusculoskeletal models are typically used to estimate muscle activations and forces that are consistent with observed motion under health...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1095260/full |
| _version_ | 1797830032496787456 |
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| author | Lysea Haggie Laura Schmid Oliver Röhrle Oliver Röhrle Thor Besier Angus McMorland Angus McMorland Harnoor Saini |
| author_facet | Lysea Haggie Laura Schmid Oliver Röhrle Oliver Röhrle Thor Besier Angus McMorland Angus McMorland Harnoor Saini |
| author_sort | Lysea Haggie |
| collection | DOAJ |
| description | Computational models of the neuromusculoskeletal system provide a deterministic approach to investigate input-output relationships in the human motor system. Neuromusculoskeletal models are typically used to estimate muscle activations and forces that are consistent with observed motion under healthy and pathological conditions. However, many movement pathologies originate in the brain, including stroke, cerebral palsy, and Parkinson’s disease, while most neuromusculoskeletal models deal exclusively with the peripheral nervous system and do not incorporate models of the motor cortex, cerebellum, or spinal cord. An integrated understanding of motor control is necessary to reveal underlying neural-input and motor-output relationships. To facilitate the development of integrated corticomuscular motor pathway models, we provide an overview of the neuromusculoskeletal modelling landscape with a focus on integrating computational models of the motor cortex, spinal cord circuitry, α-motoneurons and skeletal muscle in regard to their role in generating voluntary muscle contraction. Further, we highlight the challenges and opportunities associated with an integrated corticomuscular pathway model, such as challenges in defining neuron connectivities, modelling standardisation, and opportunities in applying models to study emergent behaviour. Integrated corticomuscular pathway models have applications in brain-machine-interaction, education, and our understanding of neurological disease. |
| first_indexed | 2024-04-09T13:29:36Z |
| format | Article |
| id | doaj.art-657a3b3bd19e45e88d7c4cbf65330fc9 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-09T13:29:36Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-657a3b3bd19e45e88d7c4cbf65330fc92023-05-10T04:46:55ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-05-011410.3389/fphys.2023.10952601095260Linking cortex and contraction—Integrating models along the corticomuscular pathwayLysea Haggie0Laura Schmid1Oliver Röhrle2Oliver Röhrle3Thor Besier4Angus McMorland5Angus McMorland6Harnoor Saini7Auckland Bioengineering Institute, University of Auckland, Auckland, New ZealandInstitute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, GermanyInstitute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, GermanyStuttgart Center for Simulation Sciences (SC SimTech), University of Stuttgart, Stuttgart, GermanyAuckland Bioengineering Institute, University of Auckland, Auckland, New ZealandAuckland Bioengineering Institute, University of Auckland, Auckland, New ZealandDepartment of Exercise Sciences, University of Auckland, Auckland, New ZealandAuckland Bioengineering Institute, University of Auckland, Auckland, New ZealandComputational models of the neuromusculoskeletal system provide a deterministic approach to investigate input-output relationships in the human motor system. Neuromusculoskeletal models are typically used to estimate muscle activations and forces that are consistent with observed motion under healthy and pathological conditions. However, many movement pathologies originate in the brain, including stroke, cerebral palsy, and Parkinson’s disease, while most neuromusculoskeletal models deal exclusively with the peripheral nervous system and do not incorporate models of the motor cortex, cerebellum, or spinal cord. An integrated understanding of motor control is necessary to reveal underlying neural-input and motor-output relationships. To facilitate the development of integrated corticomuscular motor pathway models, we provide an overview of the neuromusculoskeletal modelling landscape with a focus on integrating computational models of the motor cortex, spinal cord circuitry, α-motoneurons and skeletal muscle in regard to their role in generating voluntary muscle contraction. Further, we highlight the challenges and opportunities associated with an integrated corticomuscular pathway model, such as challenges in defining neuron connectivities, modelling standardisation, and opportunities in applying models to study emergent behaviour. Integrated corticomuscular pathway models have applications in brain-machine-interaction, education, and our understanding of neurological disease.https://www.frontiersin.org/articles/10.3389/fphys.2023.1095260/fullneuromuscularcorticospinalproprioceptionbiophysical modellingmotor controlcorticomuscular |
| spellingShingle | Lysea Haggie Laura Schmid Oliver Röhrle Oliver Röhrle Thor Besier Angus McMorland Angus McMorland Harnoor Saini Linking cortex and contraction—Integrating models along the corticomuscular pathway Frontiers in Physiology neuromuscular corticospinal proprioception biophysical modelling motor control corticomuscular |
| title | Linking cortex and contraction—Integrating models along the corticomuscular pathway |
| title_full | Linking cortex and contraction—Integrating models along the corticomuscular pathway |
| title_fullStr | Linking cortex and contraction—Integrating models along the corticomuscular pathway |
| title_full_unstemmed | Linking cortex and contraction—Integrating models along the corticomuscular pathway |
| title_short | Linking cortex and contraction—Integrating models along the corticomuscular pathway |
| title_sort | linking cortex and contraction integrating models along the corticomuscular pathway |
| topic | neuromuscular corticospinal proprioception biophysical modelling motor control corticomuscular |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1095260/full |
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