Epigenome-wide gene–age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell carcinoma patients

Epigenome-wide gene–age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell carcinoma patients

DNA methylation serves as a reversible and prognostic biomarker for oral squamous cell carcinoma (OSCC) patients. It is unclear whether the effect of DNA methylation on OSCC overall survival varies with age. As a result, we performed a two-phase gene–age interaction study of OSCC prognosis on an epi...

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Bibliographic Details
Main Authors: Ziang Xu, Yan Gu, Jiajin Chen, Xinlei Chen, Yunjie Song, Juanjuan Fan, Xinyu Ji, Yanyan Li, Wei Zhang, Ruyang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
DNA methylation
age
gene–age interaction analysis
OSCC
overall survival
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.941731/full

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