Mechanosensing Piezo channels in tissue homeostasis including their role in lungs
Piezo channels are deemed to constitute one of the most important family of mechanosensing ion channels since their discovery in 2010. With recent advances in identifying their topological structure and the discovery of the agonist Yoda1 as well as the specific inhibitor GsMTx4, it is now possible t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-06-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894018767393 |
| _version_ | 1828196618417995776 |
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| author | Ming Zhong Yulia Komarova Jalees Rehman Asrar B. Malik |
| author_facet | Ming Zhong Yulia Komarova Jalees Rehman Asrar B. Malik |
| author_sort | Ming Zhong |
| collection | DOAJ |
| description | Piezo channels are deemed to constitute one of the most important family of mechanosensing ion channels since their discovery in 2010. With recent advances in identifying their topological structure and the discovery of the agonist Yoda1 as well as the specific inhibitor GsMTx4, it is now possible to study the mechanisms by which Piezo channels are involved in physiological and pathophysiological processes. During embryonic cardiovascular development, Piezo1 senses shear stress and promotes vasculature growth. In adult mice, Piezo1 mediates the release of nitric oxide and ATP from endothelial cells to regulate blood pressure. Piezo channels also play a crucial role in cell differentiation and tissue homeostasis by exquisite mechanical force sensing. Piezo channels are also abundantly expressed in lung tissues. As the lung is exposed to complex pulmonary hemodynamics and respiratory mechanics, cells in the lung, such as microvascular endothelial cells, bear mechanical forces from blood flow shear, pulsatile strain, static pressure, and cyclic stretch due to respiratory movement. These mechanical stimuli are involved in a serial of physiological function and pathophysiological processes of the lung, many of which Piezo channels may be the key player. Mutation of genes encoding Piezo channels are also associated with hereditary human diseases, thus highlighting the critical role of Piezo channels in both tissue homeostasis and disease. |
| first_indexed | 2024-04-12T10:05:16Z |
| format | Article |
| id | doaj.art-657cb76641a14ca882e85db4129b1c8a |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-12T10:05:16Z |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-657cb76641a14ca882e85db4129b1c8a2022-12-22T03:37:28ZengWileyPulmonary Circulation2045-89402018-06-01810.1177/2045894018767393Mechanosensing Piezo channels in tissue homeostasis including their role in lungsMing ZhongYulia KomarovaJalees RehmanAsrar B. MalikPiezo channels are deemed to constitute one of the most important family of mechanosensing ion channels since their discovery in 2010. With recent advances in identifying their topological structure and the discovery of the agonist Yoda1 as well as the specific inhibitor GsMTx4, it is now possible to study the mechanisms by which Piezo channels are involved in physiological and pathophysiological processes. During embryonic cardiovascular development, Piezo1 senses shear stress and promotes vasculature growth. In adult mice, Piezo1 mediates the release of nitric oxide and ATP from endothelial cells to regulate blood pressure. Piezo channels also play a crucial role in cell differentiation and tissue homeostasis by exquisite mechanical force sensing. Piezo channels are also abundantly expressed in lung tissues. As the lung is exposed to complex pulmonary hemodynamics and respiratory mechanics, cells in the lung, such as microvascular endothelial cells, bear mechanical forces from blood flow shear, pulsatile strain, static pressure, and cyclic stretch due to respiratory movement. These mechanical stimuli are involved in a serial of physiological function and pathophysiological processes of the lung, many of which Piezo channels may be the key player. Mutation of genes encoding Piezo channels are also associated with hereditary human diseases, thus highlighting the critical role of Piezo channels in both tissue homeostasis and disease.https://doi.org/10.1177/2045894018767393 |
| spellingShingle | Ming Zhong Yulia Komarova Jalees Rehman Asrar B. Malik Mechanosensing Piezo channels in tissue homeostasis including their role in lungs Pulmonary Circulation |
| title | Mechanosensing Piezo channels in tissue homeostasis including their role in lungs |
| title_full | Mechanosensing Piezo channels in tissue homeostasis including their role in lungs |
| title_fullStr | Mechanosensing Piezo channels in tissue homeostasis including their role in lungs |
| title_full_unstemmed | Mechanosensing Piezo channels in tissue homeostasis including their role in lungs |
| title_short | Mechanosensing Piezo channels in tissue homeostasis including their role in lungs |
| title_sort | mechanosensing piezo channels in tissue homeostasis including their role in lungs |
| url | https://doi.org/10.1177/2045894018767393 |
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