NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis
The detection of NT-proBNP levels both in umbilical cord blood (UCB) samples and in serum samples collected from healthy term neonates during the neonatal period. A systematic review of relevant literature in accordance with PRISMA guidelines was conducted. For quality appraisal, the potential risk...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1416 |
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| author | Evangelos Christou Zoe Iliodromiti Abraham Pouliakis Rozeta Sokou Matina Zantiotou Chrisa Petropoulou Theodora Boutsikou Nicoletta Iacovidou |
| author_facet | Evangelos Christou Zoe Iliodromiti Abraham Pouliakis Rozeta Sokou Matina Zantiotou Chrisa Petropoulou Theodora Boutsikou Nicoletta Iacovidou |
| author_sort | Evangelos Christou |
| collection | DOAJ |
| description | The detection of NT-proBNP levels both in umbilical cord blood (UCB) samples and in serum samples collected from healthy term neonates during the neonatal period. A systematic review of relevant literature in accordance with PRISMA guidelines was conducted. For quality appraisal, the potential risk of bias was assessed using the BIOCROSS evaluation tool. The random-effects and fixed-effects models were used to calculate weighted mean differences with a corresponding 95% confidence interval. A total of forty (40) studies met the inclusion criteria for the systematic review. After further examination, eighteen (18) studies (1738 participants) from the UCB sample group and fourteen (14) studies (393 participants) from the serum sample group were selected to perform a meta-analysis. Using the fixed-effects model, the mean intervals of NT-proBNP in UCB and serum samples were 492 pg/mL (95% CI: 480–503 pg/mL) and 1341 pg/mL (95% CI: 1286–1397 pg/mL), respectively. A higher concentration of ΝΤ-proBNP was observed in the serum sample group compared to the UCB samples (<i>p</i> < 0.001). We present the intervals of NT-proBNP in UCB and in the serum of healthy term neonates. The determination of the potential effect of perinatal factors on the biomarker’s reference range was also aimed. |
| first_indexed | 2024-03-10T00:00:22Z |
| format | Article |
| id | doaj.art-6580178c71f947e087a08be6b58e230a |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:00:22Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6580178c71f947e087a08be6b58e230a2023-11-23T16:17:48ZengMDPI AGDiagnostics2075-44182022-06-01126141610.3390/diagnostics12061416NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-AnalysisEvangelos Christou0Zoe Iliodromiti1Abraham Pouliakis2Rozeta Sokou3Matina Zantiotou4Chrisa Petropoulou5Theodora Boutsikou6Nicoletta Iacovidou7Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, Greece2nd Department of Pathology, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, 124 61 Athens, GreeceNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceChildren’s Hospital Agia Sofia, 115 27 Athens, GreeceNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceThe detection of NT-proBNP levels both in umbilical cord blood (UCB) samples and in serum samples collected from healthy term neonates during the neonatal period. A systematic review of relevant literature in accordance with PRISMA guidelines was conducted. For quality appraisal, the potential risk of bias was assessed using the BIOCROSS evaluation tool. The random-effects and fixed-effects models were used to calculate weighted mean differences with a corresponding 95% confidence interval. A total of forty (40) studies met the inclusion criteria for the systematic review. After further examination, eighteen (18) studies (1738 participants) from the UCB sample group and fourteen (14) studies (393 participants) from the serum sample group were selected to perform a meta-analysis. Using the fixed-effects model, the mean intervals of NT-proBNP in UCB and serum samples were 492 pg/mL (95% CI: 480–503 pg/mL) and 1341 pg/mL (95% CI: 1286–1397 pg/mL), respectively. A higher concentration of ΝΤ-proBNP was observed in the serum sample group compared to the UCB samples (<i>p</i> < 0.001). We present the intervals of NT-proBNP in UCB and in the serum of healthy term neonates. The determination of the potential effect of perinatal factors on the biomarker’s reference range was also aimed.https://www.mdpi.com/2075-4418/12/6/1416biomarkerneonateNt-proBnpserumumbilical cord |
| spellingShingle | Evangelos Christou Zoe Iliodromiti Abraham Pouliakis Rozeta Sokou Matina Zantiotou Chrisa Petropoulou Theodora Boutsikou Nicoletta Iacovidou NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis Diagnostics biomarker neonate Nt-proBnp serum umbilical cord |
| title | NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis |
| title_full | NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis |
| title_fullStr | NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis |
| title_short | NT-proBNP Concentrations in the Umbilical Cord and Serum of Term Neonates: A Systematic Review and Meta-Analysis |
| title_sort | nt probnp concentrations in the umbilical cord and serum of term neonates a systematic review and meta analysis |
| topic | biomarker neonate Nt-proBnp serum umbilical cord |
| url | https://www.mdpi.com/2075-4418/12/6/1416 |
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