Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics

Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics

Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of schizophrenia treatment and nearly all share the common feature of dopamine D2 receptor occupancy, whereas glutamatergic...

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Bibliographic Details
Main Authors: Andrea de Bartolomeis, Licia Vellucci, Mark C. Austin, Giuseppe De Simone, Annarita Barone
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomolecules
Subjects:
antipsychotics
treatment-resistant schizophrenia
NMDA
dopamine
glutamate
D-serine
Online Access:https://www.mdpi.com/2218-273X/12/7/909

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