The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report
A Y842D mutation within the activation loop of fms-like tyrosine kinase 3 (FLT3) has been shown to confer strong resistance to sorafenib in vitro . Whether this type of mutation exerts clinically significant effects in patients with acute myeloid leukaemia (AML) remains unclear. Here, a novel Y842D...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221097774 |
| _version_ | 1818201284521492480 |
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| author | Shujiao He Minjie Zhang Jieying Li Weiqiang Zhao Li Yu Ying Han Yanbin Pang |
| author_facet | Shujiao He Minjie Zhang Jieying Li Weiqiang Zhao Li Yu Ying Han Yanbin Pang |
| author_sort | Shujiao He |
| collection | DOAJ |
| description | A Y842D mutation within the activation loop of fms-like tyrosine kinase 3 (FLT3) has been shown to confer strong resistance to sorafenib in vitro . Whether this type of mutation exerts clinically significant effects in patients with acute myeloid leukaemia (AML) remains unclear. Here, a novel Y842D activating mutation within the kinase domain of FLT3, in a pregnant patient with de novo hyperleucocyte acute myeloid leukaemia, is described. Following induction failure with standard dose idarubicin and cytarabine (IA), the patient received re-induction combined with midostaurin, a promising agent targeting mutant-FLT3, and IA regimen. Fortunately, morphological remission was achieved. During the period of midostaurin treatment, the patient exhibited a symptom that was characteristic of differentiation syndrome, which disappeared following treatment with methylprednisolone. The present case revealed that Y842D, an uncommon activating mutation in the activation loop of FLT3, may be a midostaurin-sensitive mutation type in patients with acute myeloid leukaemia. |
| first_indexed | 2024-12-12T02:51:07Z |
| format | Article |
| id | doaj.art-6583c6dd00914fdcbc555e7c21fb9213 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-12T02:51:07Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-6583c6dd00914fdcbc555e7c21fb92132022-12-22T00:40:53ZengSAGE PublishingJournal of International Medical Research1473-23002022-05-015010.1177/03000605221097774The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case reportShujiao HeMinjie ZhangJieying LiWeiqiang ZhaoLi YuYing HanYanbin PangA Y842D mutation within the activation loop of fms-like tyrosine kinase 3 (FLT3) has been shown to confer strong resistance to sorafenib in vitro . Whether this type of mutation exerts clinically significant effects in patients with acute myeloid leukaemia (AML) remains unclear. Here, a novel Y842D activating mutation within the kinase domain of FLT3, in a pregnant patient with de novo hyperleucocyte acute myeloid leukaemia, is described. Following induction failure with standard dose idarubicin and cytarabine (IA), the patient received re-induction combined with midostaurin, a promising agent targeting mutant-FLT3, and IA regimen. Fortunately, morphological remission was achieved. During the period of midostaurin treatment, the patient exhibited a symptom that was characteristic of differentiation syndrome, which disappeared following treatment with methylprednisolone. The present case revealed that Y842D, an uncommon activating mutation in the activation loop of FLT3, may be a midostaurin-sensitive mutation type in patients with acute myeloid leukaemia.https://doi.org/10.1177/03000605221097774 |
| spellingShingle | Shujiao He Minjie Zhang Jieying Li Weiqiang Zhao Li Yu Ying Han Yanbin Pang The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report Journal of International Medical Research |
| title | The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report |
| title_full | The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report |
| title_fullStr | The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report |
| title_full_unstemmed | The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report |
| title_short | The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report |
| title_sort | flt3 y842d mutation may be highly sensitive to midostaurin a case report |
| url | https://doi.org/10.1177/03000605221097774 |
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