Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic
Recent advancements in molecular testing, the availability of cost-effective technology, and novel approaches to clinical trial design have facilitated the implementation of tumor genome sequencing into standard of care oncology practices. Current models of precision oncology practice include specia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
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| Series: | Pharmacy |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2226-4787/8/1/32 |
| _version_ | 1811213413973491712 |
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| author | Farah Raheem Pauline Kim Meagan Grove Patrick J. Kiel |
| author_facet | Farah Raheem Pauline Kim Meagan Grove Patrick J. Kiel |
| author_sort | Farah Raheem |
| collection | DOAJ |
| description | Recent advancements in molecular testing, the availability of cost-effective technology, and novel approaches to clinical trial design have facilitated the implementation of tumor genome sequencing into standard of care oncology practices. Current models of precision oncology practice include specialized clinics or consultation services based on a molecular tumor board (MTB) approach. MTBs are comprised of interprofessional teams of clinicians and scientists who evaluate tumors at the molecular level to guide patient-specific targeted therapy. The practice of precision oncology utilizing MTB-based models is an emerging approach, transforming precision genomics from a novel concept into clinical practice. This rapid shift in practice from cytotoxic therapy to targeted medicine poses challenges, yet brings exciting opportunities to clinical pharmacists practicing in hematology and oncology. Only a few precision genomics programs in the United States have a strong pharmacy presence with oncology pharmacists serving in leadership roles in research, interpreting genomic sequencing, making treatment recommendations, and facilitating off-label drug procurement. This article describes the experience of the precision medicine clinic at the Indiana University Health Simon Cancer Center, with emphasis on the role of the pharmacist in the precision oncology initiative. |
| first_indexed | 2024-04-12T05:46:19Z |
| format | Article |
| id | doaj.art-6584e95d415b46ceb3fa1b3e51a5ba5c |
| institution | Directory Open Access Journal |
| issn | 2226-4787 |
| language | English |
| last_indexed | 2024-04-12T05:46:19Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmacy |
| spelling | doaj.art-6584e95d415b46ceb3fa1b3e51a5ba5c2022-12-22T03:45:27ZengMDPI AGPharmacy2226-47872020-03-01813210.3390/pharmacy8010032pharmacy8010032Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care ClinicFarah Raheem0Pauline Kim1Meagan Grove2Patrick J. Kiel3Indiana University Health Simon Cancer Center, Indianapolis, IN 46202, USAIndiana University Health Simon Cancer Center, Indianapolis, IN 46202, USAIndiana University Health Simon Cancer Center, Indianapolis, IN 46202, USAIndiana University Health Simon Cancer Center, Indianapolis, IN 46202, USARecent advancements in molecular testing, the availability of cost-effective technology, and novel approaches to clinical trial design have facilitated the implementation of tumor genome sequencing into standard of care oncology practices. Current models of precision oncology practice include specialized clinics or consultation services based on a molecular tumor board (MTB) approach. MTBs are comprised of interprofessional teams of clinicians and scientists who evaluate tumors at the molecular level to guide patient-specific targeted therapy. The practice of precision oncology utilizing MTB-based models is an emerging approach, transforming precision genomics from a novel concept into clinical practice. This rapid shift in practice from cytotoxic therapy to targeted medicine poses challenges, yet brings exciting opportunities to clinical pharmacists practicing in hematology and oncology. Only a few precision genomics programs in the United States have a strong pharmacy presence with oncology pharmacists serving in leadership roles in research, interpreting genomic sequencing, making treatment recommendations, and facilitating off-label drug procurement. This article describes the experience of the precision medicine clinic at the Indiana University Health Simon Cancer Center, with emphasis on the role of the pharmacist in the precision oncology initiative.https://www.mdpi.com/2226-4787/8/1/32precision genomicsprecision medicineprecision oncologytargeted therapyoncology pharmacistmolecular tumor boardnext generation sequencing |
| spellingShingle | Farah Raheem Pauline Kim Meagan Grove Patrick J. Kiel Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic Pharmacy precision genomics precision medicine precision oncology targeted therapy oncology pharmacist molecular tumor board next generation sequencing |
| title | Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic |
| title_full | Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic |
| title_fullStr | Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic |
| title_full_unstemmed | Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic |
| title_short | Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic |
| title_sort | precision genomic practice in oncology pharmacist role and experience in an ambulatory care clinic |
| topic | precision genomics precision medicine precision oncology targeted therapy oncology pharmacist molecular tumor board next generation sequencing |
| url | https://www.mdpi.com/2226-4787/8/1/32 |
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