Mitochondrial Dynamics in Stem Cells and Differentiation
Mitochondria are highly dynamic organelles that continuously change their shape. Their main function is adenosine triphosphate (ATP) production; however, they are additionally involved in a variety of cellular phenomena, such as apoptosis, cell cycle, proliferation, differentiation, reprogramming, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/19/12/3893 |
| _version_ | 1811278476311789568 |
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| author | Bong Jong Seo Sang Hoon Yoon Jeong Tae Do |
| author_facet | Bong Jong Seo Sang Hoon Yoon Jeong Tae Do |
| author_sort | Bong Jong Seo |
| collection | DOAJ |
| description | Mitochondria are highly dynamic organelles that continuously change their shape. Their main function is adenosine triphosphate (ATP) production; however, they are additionally involved in a variety of cellular phenomena, such as apoptosis, cell cycle, proliferation, differentiation, reprogramming, and aging. The change in mitochondrial morphology is closely related to the functionality of mitochondria. Normal mitochondrial dynamics are critical for cellular function, embryonic development, and tissue formation. Thus, defects in proteins involved in mitochondrial dynamics that control mitochondrial fusion and fission can affect cellular differentiation, proliferation, cellular reprogramming, and aging. Here, we review the processes and proteins involved in mitochondrial dynamics and their various associated cellular phenomena. |
| first_indexed | 2024-04-13T00:36:35Z |
| format | Article |
| id | doaj.art-65865e45cdb44501a46b9f7755abf842 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T00:36:35Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-65865e45cdb44501a46b9f7755abf8422022-12-22T03:10:18ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-12-011912389310.3390/ijms19123893ijms19123893Mitochondrial Dynamics in Stem Cells and DifferentiationBong Jong Seo0Sang Hoon Yoon1Jeong Tae Do2Department of Stem Cell and Regenerative Biotechnology, Konkuk Institute of Technology, Konkuk University, Seoul 05020, KoreaDepartment of Stem Cell and Regenerative Biotechnology, Konkuk Institute of Technology, Konkuk University, Seoul 05020, KoreaDepartment of Stem Cell and Regenerative Biotechnology, Konkuk Institute of Technology, Konkuk University, Seoul 05020, KoreaMitochondria are highly dynamic organelles that continuously change their shape. Their main function is adenosine triphosphate (ATP) production; however, they are additionally involved in a variety of cellular phenomena, such as apoptosis, cell cycle, proliferation, differentiation, reprogramming, and aging. The change in mitochondrial morphology is closely related to the functionality of mitochondria. Normal mitochondrial dynamics are critical for cellular function, embryonic development, and tissue formation. Thus, defects in proteins involved in mitochondrial dynamics that control mitochondrial fusion and fission can affect cellular differentiation, proliferation, cellular reprogramming, and aging. Here, we review the processes and proteins involved in mitochondrial dynamics and their various associated cellular phenomena.https://www.mdpi.com/1422-0067/19/12/3893mitochondriamitochondrial dynamicsfusionfissionpluripotencydifferentiation |
| spellingShingle | Bong Jong Seo Sang Hoon Yoon Jeong Tae Do Mitochondrial Dynamics in Stem Cells and Differentiation International Journal of Molecular Sciences mitochondria mitochondrial dynamics fusion fission pluripotency differentiation |
| title | Mitochondrial Dynamics in Stem Cells and Differentiation |
| title_full | Mitochondrial Dynamics in Stem Cells and Differentiation |
| title_fullStr | Mitochondrial Dynamics in Stem Cells and Differentiation |
| title_full_unstemmed | Mitochondrial Dynamics in Stem Cells and Differentiation |
| title_short | Mitochondrial Dynamics in Stem Cells and Differentiation |
| title_sort | mitochondrial dynamics in stem cells and differentiation |
| topic | mitochondria mitochondrial dynamics fusion fission pluripotency differentiation |
| url | https://www.mdpi.com/1422-0067/19/12/3893 |
| work_keys_str_mv | AT bongjongseo mitochondrialdynamicsinstemcellsanddifferentiation AT sanghoonyoon mitochondrialdynamicsinstemcellsanddifferentiation AT jeongtaedo mitochondrialdynamicsinstemcellsanddifferentiation |