Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
ABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The unde...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481&lng=en&tlng=en |
| _version_ | 1818573280798310400 |
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| author | Carlos Henrique Pires Ratto Tavares Bello João Sequeira Duarte Carlos Vasconcelos |
| author_facet | Carlos Henrique Pires Ratto Tavares Bello João Sequeira Duarte Carlos Vasconcelos |
| author_sort | Carlos Henrique Pires Ratto Tavares Bello |
| collection | DOAJ |
| description | ABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited. |
| first_indexed | 2024-12-15T00:09:04Z |
| format | Article |
| id | doaj.art-658868714183456aa1311aee07437b4d |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-12-15T00:09:04Z |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-658868714183456aa1311aee07437b4d2022-12-21T22:42:38ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-823939448148510.5935/0101-2800.20170086S0101-28002017000400481Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature reviewCarlos Henrique Pires Ratto Tavares BelloJoão Sequeira DuarteCarlos VasconcelosABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481&lng=en&tlng=enacidoseacidose tubular renaldiabetes mellitushiperpotassemiahipoaldosteronismo |
| spellingShingle | Carlos Henrique Pires Ratto Tavares Bello João Sequeira Duarte Carlos Vasconcelos Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review Brazilian Journal of Nephrology acidose acidose tubular renal diabetes mellitus hiperpotassemia hipoaldosteronismo |
| title | Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
| title_full | Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
| title_fullStr | Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
| title_full_unstemmed | Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
| title_short | Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
| title_sort | diabetes mellitus and hyperkalemic renal tubular acidosis case reports and literature review |
| topic | acidose acidose tubular renal diabetes mellitus hiperpotassemia hipoaldosteronismo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481&lng=en&tlng=en |
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