Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators
Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, ni...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/9/2645 |
| _version_ | 1797503805400547328 |
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| author | George Papageorgiou John E. T. Corrie |
| author_facet | George Papageorgiou John E. T. Corrie |
| author_sort | George Papageorgiou |
| collection | DOAJ |
| description | Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions. |
| first_indexed | 2024-03-10T03:55:35Z |
| format | Article |
| id | doaj.art-6588e769a44a441e838958ddd62d705a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:55:35Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6588e769a44a441e838958ddd62d705a2023-11-23T08:47:32ZengMDPI AGMolecules1420-30492022-04-01279264510.3390/molecules27092645Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators George Papageorgiou0John E. T. Corrie1Chemical Biology STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UKMRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UKNeuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.https://www.mdpi.com/1420-3049/27/9/2645nitroindoline cagescalcium chelatorschemical synthesisphotolysisphotostability |
| spellingShingle | George Papageorgiou John E. T. Corrie Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators Molecules nitroindoline cages calcium chelators chemical synthesis photolysis photostability |
| title | Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators |
| title_full | Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators |
| title_fullStr | Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators |
| title_full_unstemmed | Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators |
| title_short | Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators |
| title_sort | synthesis and photolytic assessment of nitroindolinyl caged calcium ion chelators |
| topic | nitroindoline cages calcium chelators chemical synthesis photolysis photostability |
| url | https://www.mdpi.com/1420-3049/27/9/2645 |
| work_keys_str_mv | AT georgepapageorgiou synthesisandphotolyticassessmentofnitroindolinylcagedcalciumionchelators AT johnetcorrie synthesisandphotolyticassessmentofnitroindolinylcagedcalciumionchelators |