The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis
Abstract The neutrophil-to-lymphocyte ratio is used to reflect body's inflammatory status with prognostic value in different cancers. We aimed to investigate the influence of preoperative NLR in the prognosis of CRLM patients receiving surgery using meta-analysis. Data in Cochrane Library, PubM...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-023-02876-z |
| _version_ | 1797863464062943232 |
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| author | Yanqing Li Tianxiang Xu Xin Wang Xiangdong Jia Meng Ren Xiaoxia Wang |
| author_facet | Yanqing Li Tianxiang Xu Xin Wang Xiangdong Jia Meng Ren Xiaoxia Wang |
| author_sort | Yanqing Li |
| collection | DOAJ |
| description | Abstract The neutrophil-to-lymphocyte ratio is used to reflect body's inflammatory status with prognostic value in different cancers. We aimed to investigate the influence of preoperative NLR in the prognosis of CRLM patients receiving surgery using meta-analysis. Data in Cochrane Library, PubMed, Embase, and Web of Science databases created before October 2022 were recruited. Meta-analysis was carried out with RevMan 5.3 and Stata16 software, and the primary outcome indicators included overall survival (OS), and secondary outcome indicators included disease-free survival (DFS) and relapse-free survival (RFS). The pooled risk ratio (HR) and 95% confidence interval (CI) for each outcome indicator were determined using random-effects models or fixed-effects models. The pooled odds ratio (OR) and corresponding 95% confidence intervals (CI) for NLR and clinicopathological characteristics were determined with a fixed-effects model. 18 papers published between 2008 and 2022 (3184 patients in total) were included. The pooled analysis found that high preoperative NLR was correlated with poor OS (multivariate HR = 1.83, 95% CI = 1.61–2.08, p < 0.01), DFS (multivariate HR = 1.78, 95% CI = 1.16–2.71, p < 0.01) and RFS (multivariate HR = 1.46, 95% CI = 1.15–1.85, p < 0.01), but NLR was not related to clinicopathological features of CRLM patients correlation. In conclusion, NLR is an independent risk factor for poor prognosis in patients with CRLM. More large-scale clinical researches are required in the future to demonstrate the inclusion of preoperative NLR as a prognostic indicator for CRLM patients to guide postoperative adjuvant chemotherapy. |
| first_indexed | 2024-04-09T22:36:00Z |
| format | Article |
| id | doaj.art-658b7ac6fb2e4be59c240e0c74469d47 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-09T22:36:00Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-658b7ac6fb2e4be59c240e0c74469d472023-03-22T12:26:46ZengBMCCancer Cell International1475-28672023-02-0123111410.1186/s12935-023-02876-zThe prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysisYanqing Li0Tianxiang Xu1Xin Wang2Xiangdong Jia3Meng Ren4Xiaoxia Wang5Graduate School of Baotou Medical College, Inner Mongolia University of Science and TechnologyAbdominal Tumor Surgery, Center of Tumor, Inner Mongolia People’s HospitalGraduate School of Baotou Medical College, Inner Mongolia University of Science and TechnologyAbdominal Tumor Surgery, Center of Tumor, Inner Mongolia People’s HospitalAbdominal Tumor Surgery, Center of Tumor, Inner Mongolia People’s HospitalIntensive Care Unit, Inner Mongolia People’s HospitalAbstract The neutrophil-to-lymphocyte ratio is used to reflect body's inflammatory status with prognostic value in different cancers. We aimed to investigate the influence of preoperative NLR in the prognosis of CRLM patients receiving surgery using meta-analysis. Data in Cochrane Library, PubMed, Embase, and Web of Science databases created before October 2022 were recruited. Meta-analysis was carried out with RevMan 5.3 and Stata16 software, and the primary outcome indicators included overall survival (OS), and secondary outcome indicators included disease-free survival (DFS) and relapse-free survival (RFS). The pooled risk ratio (HR) and 95% confidence interval (CI) for each outcome indicator were determined using random-effects models or fixed-effects models. The pooled odds ratio (OR) and corresponding 95% confidence intervals (CI) for NLR and clinicopathological characteristics were determined with a fixed-effects model. 18 papers published between 2008 and 2022 (3184 patients in total) were included. The pooled analysis found that high preoperative NLR was correlated with poor OS (multivariate HR = 1.83, 95% CI = 1.61–2.08, p < 0.01), DFS (multivariate HR = 1.78, 95% CI = 1.16–2.71, p < 0.01) and RFS (multivariate HR = 1.46, 95% CI = 1.15–1.85, p < 0.01), but NLR was not related to clinicopathological features of CRLM patients correlation. In conclusion, NLR is an independent risk factor for poor prognosis in patients with CRLM. More large-scale clinical researches are required in the future to demonstrate the inclusion of preoperative NLR as a prognostic indicator for CRLM patients to guide postoperative adjuvant chemotherapy.https://doi.org/10.1186/s12935-023-02876-zNLRColorectal cancerLiver metastasisPrognosisMeta-analysis |
| spellingShingle | Yanqing Li Tianxiang Xu Xin Wang Xiangdong Jia Meng Ren Xiaoxia Wang The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis Cancer Cell International NLR Colorectal cancer Liver metastasis Prognosis Meta-analysis |
| title | The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis |
| title_full | The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis |
| title_fullStr | The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis |
| title_full_unstemmed | The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis |
| title_short | The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis |
| title_sort | prognostic utility of preoperative neutrophil to lymphocyte ratio nlr in patients with colorectal liver metastasis a systematic review and meta analysis |
| topic | NLR Colorectal cancer Liver metastasis Prognosis Meta-analysis |
| url | https://doi.org/10.1186/s12935-023-02876-z |
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