Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the important health issues with high prevalence worldwide. However, there is no approved medication for that. As one of the indicators of metabolic syndrome, uric acid might play a role in the pathogenesis of NAFLD. In this study, we...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Research Center for Rational Use of Drugs (RCRUD)
2022-12-01
|
| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/543 |
| _version_ | 1797943714604122112 |
|---|---|
| author | Elnaz Khani Manouchehr Khoshbaten Fariba Pourkarim Mohammad Asghari Jafarabadi Elnaz Shaseb |
| author_facet | Elnaz Khani Manouchehr Khoshbaten Fariba Pourkarim Mohammad Asghari Jafarabadi Elnaz Shaseb |
| author_sort | Elnaz Khani |
| collection | DOAJ |
| description |
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the important health issues with high prevalence worldwide. However, there is no approved medication for that. As one of the indicators of metabolic syndrome, uric acid might play a role in the pathogenesis of NAFLD. In this study, we aimed to determine the correlation between serum uric acid level, liver enzymes, and ultrasonographic grading of NAFLD.
Methods: This cross-sectional study included patients aged 18-65 with NAFLD. Patients with other metabolic disorders and a history of using alcohol or medications that alter uric acid levels were excluded. The patients' serum uric acid, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels, and ultrasonographic grading of NAFLD at baseline, third month, and sixth month were collected.
Results: Of the 3000 patients, 500 patients met the eligibility criteria. The results showed that there is a significant positive relationship between ALT and serum uric acid level at the first (P = .01), third (P = .01), and sixth month (P = .01). Furthermore, there was a significant positive correlation between AST and serum uric acid level at the sixth month (P = 0.001). The comparison of 249 patients' ultrasonographic grading showed no significant correlation with serum uric acid levels.
Conclusion: To conclude, the serum uric acid level significantly correlates with ALT and AST over six months but not with the ultrasonographic grading. Further studies are required to determine the role of uric acid-lowering agents in the treatment of NAFLD.
|
| first_indexed | 2024-04-10T20:28:33Z |
| format | Article |
| id | doaj.art-658c3d3adf25411ba82e241c1ee2dd9c |
| institution | Directory Open Access Journal |
| issn | 2322-4630 2322-4509 |
| language | English |
| last_indexed | 2024-04-10T20:28:33Z |
| publishDate | 2022-12-01 |
| publisher | Research Center for Rational Use of Drugs (RCRUD) |
| record_format | Article |
| series | Journal of Pharmaceutical Care |
| spelling | doaj.art-658c3d3adf25411ba82e241c1ee2dd9c2023-01-25T07:55:20ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092022-12-0110410.18502/jpc.v10i4.11582Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional StudyElnaz Khani0Manouchehr Khoshbaten1Fariba Pourkarim2Mohammad Asghari Jafarabadi3Elnaz Shaseb4Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Science, Tabriz, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Statistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Background: Non-alcoholic fatty liver disease (NAFLD) is one of the important health issues with high prevalence worldwide. However, there is no approved medication for that. As one of the indicators of metabolic syndrome, uric acid might play a role in the pathogenesis of NAFLD. In this study, we aimed to determine the correlation between serum uric acid level, liver enzymes, and ultrasonographic grading of NAFLD. Methods: This cross-sectional study included patients aged 18-65 with NAFLD. Patients with other metabolic disorders and a history of using alcohol or medications that alter uric acid levels were excluded. The patients' serum uric acid, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels, and ultrasonographic grading of NAFLD at baseline, third month, and sixth month were collected. Results: Of the 3000 patients, 500 patients met the eligibility criteria. The results showed that there is a significant positive relationship between ALT and serum uric acid level at the first (P = .01), third (P = .01), and sixth month (P = .01). Furthermore, there was a significant positive correlation between AST and serum uric acid level at the sixth month (P = 0.001). The comparison of 249 patients' ultrasonographic grading showed no significant correlation with serum uric acid levels. Conclusion: To conclude, the serum uric acid level significantly correlates with ALT and AST over six months but not with the ultrasonographic grading. Further studies are required to determine the role of uric acid-lowering agents in the treatment of NAFLD. https://jpc.tums.ac.ir/index.php/jpc/article/view/543Alanine transaminaseAspartate aminotransferaseGastroenterologyLiver diseasesTherapeuticsUltrasonography |
| spellingShingle | Elnaz Khani Manouchehr Khoshbaten Fariba Pourkarim Mohammad Asghari Jafarabadi Elnaz Shaseb Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study Journal of Pharmaceutical Care Alanine transaminase Aspartate aminotransferase Gastroenterology Liver diseases Therapeutics Ultrasonography |
| title | Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study |
| title_full | Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study |
| title_fullStr | Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study |
| title_full_unstemmed | Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study |
| title_short | Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study |
| title_sort | correlation between serum uric acid and non alcoholic fatty liver disease a cross sectional study |
| topic | Alanine transaminase Aspartate aminotransferase Gastroenterology Liver diseases Therapeutics Ultrasonography |
| url | https://jpc.tums.ac.ir/index.php/jpc/article/view/543 |
| work_keys_str_mv | AT elnazkhani correlationbetweenserumuricacidandnonalcoholicfattyliverdiseaseacrosssectionalstudy AT manouchehrkhoshbaten correlationbetweenserumuricacidandnonalcoholicfattyliverdiseaseacrosssectionalstudy AT faribapourkarim correlationbetweenserumuricacidandnonalcoholicfattyliverdiseaseacrosssectionalstudy AT mohammadasgharijafarabadi correlationbetweenserumuricacidandnonalcoholicfattyliverdiseaseacrosssectionalstudy AT elnazshaseb correlationbetweenserumuricacidandnonalcoholicfattyliverdiseaseacrosssectionalstudy |