Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast
Asynchronicity in fungal spore germination makes transcriptomic analysis of the process challenging. Here, the authors assay single cell transcriptomes of germinating yeast cells and find that one of the histone H3 genes shows fluctuating expression, disruption of which causes germination defects.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15060-y |
| _version_ | 1818423111539752960 |
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| author | Hayato Tsuyuzaki Masahito Hosokawa Koji Arikawa Takuya Yoda Naoyuki Okada Haruko Takeyama Masamitsu Sato |
| author_facet | Hayato Tsuyuzaki Masahito Hosokawa Koji Arikawa Takuya Yoda Naoyuki Okada Haruko Takeyama Masamitsu Sato |
| author_sort | Hayato Tsuyuzaki |
| collection | DOAJ |
| description | Asynchronicity in fungal spore germination makes transcriptomic analysis of the process challenging. Here, the authors assay single cell transcriptomes of germinating yeast cells and find that one of the histone H3 genes shows fluctuating expression, disruption of which causes germination defects. |
| first_indexed | 2024-12-14T13:36:57Z |
| format | Article |
| id | doaj.art-658c9b12092e4c3f8d4e63e3deb0a930 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:36:57Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-658c9b12092e4c3f8d4e63e3deb0a9302022-12-21T22:59:33ZengNature PortfolioNature Communications2041-17232020-03-0111111110.1038/s41467-020-15060-yTime-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeastHayato Tsuyuzaki0Masahito Hosokawa1Koji Arikawa2Takuya Yoda3Naoyuki Okada4Haruko Takeyama5Masamitsu Sato6Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda UniversityResearch Organization for Nano and Life Innovation, Waseda UniversityComputational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and TechnologyDepartment of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda UniversityDepartment of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda UniversityDepartment of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda UniversityDepartment of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda UniversityAsynchronicity in fungal spore germination makes transcriptomic analysis of the process challenging. Here, the authors assay single cell transcriptomes of germinating yeast cells and find that one of the histone H3 genes shows fluctuating expression, disruption of which causes germination defects.https://doi.org/10.1038/s41467-020-15060-y |
| spellingShingle | Hayato Tsuyuzaki Masahito Hosokawa Koji Arikawa Takuya Yoda Naoyuki Okada Haruko Takeyama Masamitsu Sato Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast Nature Communications |
| title | Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast |
| title_full | Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast |
| title_fullStr | Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast |
| title_full_unstemmed | Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast |
| title_short | Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast |
| title_sort | time lapse single cell transcriptomics reveals modulation of histone h3 for dormancy breaking in fission yeast |
| url | https://doi.org/10.1038/s41467-020-15060-y |
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