The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases

The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases

Prion diseases are neurodegenerative pathologies characterized by the accumulation of a protease-resistant form of the cellular prion protein named prion protein scrapie (PrPSc) in the brain. PrPSc accumulation in the endoplasmic reticulum (ER) result in a dysregulated calcium (Ca2+) homeostasis and...

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Bibliographic Details
Main Authors:	Lifeng Yang, Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-05-01
Series:	Frontiers in Aging Neuroscience
Subjects:	prion diseases prion protein scrapie (PrPSc) endoplasmic reticulum (ER) unfolded protein response (UPR) mitogen-activated protein kinases (MAPKs) neurodegenerative diseases
Online Access:	http://journal.frontiersin.org/article/10.3389/fnagi.2017.00120/full

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