Collaborative Cross Mice Yield Genetic Modifiers for <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Infection in Human Lung Disease

Collaborative Cross Mice Yield Genetic Modifiers for <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Infection in Human Lung Disease

ABSTRACT Human genetics influence a range of pathological and clinical phenotypes in respiratory infections; however, the contributions of disease modifiers remain underappreciated. We exploited the Collaborative Cross (CC) mouse genetic-reference population to map genetic modifiers that affect the...

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Bibliographic Details
Main Authors: Nicola Ivan Lorè, Barbara Sipione, Gengming He, Lisa J. Strug, Hanifa J. Atamni, Alexandra Dorman, Richard Mott, Fuad A. Iraqi, Alessandra Bragonzi
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
Pseudomonas aeruginosa
gene modifiers
respiratory infection
mouse model
Online Access:https://journals.asm.org/doi/10.1128/mBio.00097-20

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