IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis
BackgroundSpontaneous bacterial peritonitis (SBP) is common in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). The prognostic value of interleukin-related serum markers for patients with ACLF is coming to the fore. However, there is an unmet need to predict the sur...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1188300/full |
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| author | Linxiang Liu Linxiang Liu Nanxi Xiao Nanxi Xiao Peng Chen Peng Chen Xuan Zhu Xuan Zhu |
| author_facet | Linxiang Liu Linxiang Liu Nanxi Xiao Nanxi Xiao Peng Chen Peng Chen Xuan Zhu Xuan Zhu |
| author_sort | Linxiang Liu |
| collection | DOAJ |
| description | BackgroundSpontaneous bacterial peritonitis (SBP) is common in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). The prognostic value of interleukin-related serum markers for patients with ACLF is coming to the fore. However, there is an unmet need to predict the survival of such patients. We aimed to analyze the independent predictors of 28- and 90-day mortality in HBV-ACLF patients with SBP.MethodsThis was a retrospective study that included 368 patients with HBV-ACLF. In the SBP group, logistic regression analysis was used to understand the independent predictors of mortality at 28-day and 90-day. The accuracy of prediction was analyzed using the area under the receiver operating characteristic curve (AUROC). Finally, decision curve analysis (DCA) was used to determine the clinical utility value.ResultsInterleukin 10 (IL-10) levels were statistically significantly different between the HBV-ACLF group with SBP and without. Aspartate aminotransferase (AST), serum sodium, IL-10 and vasoactive drug treatment were independent risk factors for 28-day mortality. International normalized ratio (INR), AST and IL-10 were independent risk factors for 90-day mortality. IL-10 combined with the Chinese Severe Hepatitis B Study Group-ACLF II score (COSH-ACLF IIs) had excellent performance in predicting 28- and 90-day mortality (AUCs: 0.848 and 0.823, respectively). DCA analysis suggests promising clinical utility.ConclusionIL-10 is an independent predictor of mortality at 28- and 90-day in HBV-ACLF patients with SBP and predictive performance is improved when combined with COSH-ACLF IIs. |
| first_indexed | 2024-03-11T21:30:47Z |
| format | Article |
| id | doaj.art-658fa3983d424abcada2ff659cdbd8c1 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T21:30:47Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-658fa3983d424abcada2ff659cdbd8c12023-09-27T09:16:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-09-011010.3389/fmed.2023.11883001188300IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitisLinxiang Liu0Linxiang Liu1Nanxi Xiao2Nanxi Xiao3Peng Chen4Peng Chen5Xuan Zhu6Xuan Zhu7Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Clinical Research Center for Gastroenterology, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Clinical Research Center for Gastroenterology, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Clinical Research Center for Gastroenterology, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Clinical Research Center for Gastroenterology, Nanchang, Jiangxi, ChinaBackgroundSpontaneous bacterial peritonitis (SBP) is common in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). The prognostic value of interleukin-related serum markers for patients with ACLF is coming to the fore. However, there is an unmet need to predict the survival of such patients. We aimed to analyze the independent predictors of 28- and 90-day mortality in HBV-ACLF patients with SBP.MethodsThis was a retrospective study that included 368 patients with HBV-ACLF. In the SBP group, logistic regression analysis was used to understand the independent predictors of mortality at 28-day and 90-day. The accuracy of prediction was analyzed using the area under the receiver operating characteristic curve (AUROC). Finally, decision curve analysis (DCA) was used to determine the clinical utility value.ResultsInterleukin 10 (IL-10) levels were statistically significantly different between the HBV-ACLF group with SBP and without. Aspartate aminotransferase (AST), serum sodium, IL-10 and vasoactive drug treatment were independent risk factors for 28-day mortality. International normalized ratio (INR), AST and IL-10 were independent risk factors for 90-day mortality. IL-10 combined with the Chinese Severe Hepatitis B Study Group-ACLF II score (COSH-ACLF IIs) had excellent performance in predicting 28- and 90-day mortality (AUCs: 0.848 and 0.823, respectively). DCA analysis suggests promising clinical utility.ConclusionIL-10 is an independent predictor of mortality at 28- and 90-day in HBV-ACLF patients with SBP and predictive performance is improved when combined with COSH-ACLF IIs.https://www.frontiersin.org/articles/10.3389/fmed.2023.1188300/fullinterleukin 10hepatitis B virusacute-on-chronic liver failureprognosisCOSSH-ACLF II score |
| spellingShingle | Linxiang Liu Linxiang Liu Nanxi Xiao Nanxi Xiao Peng Chen Peng Chen Xuan Zhu Xuan Zhu IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis Frontiers in Medicine interleukin 10 hepatitis B virus acute-on-chronic liver failure prognosis COSSH-ACLF II score |
| title | IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis |
| title_full | IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis |
| title_fullStr | IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis |
| title_full_unstemmed | IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis |
| title_short | IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis |
| title_sort | il 10 predicts the prognosis of patients with hepatitis b virus related acute on chronic liver failure combined with spontaneous bacterial peritonitis |
| topic | interleukin 10 hepatitis B virus acute-on-chronic liver failure prognosis COSSH-ACLF II score |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1188300/full |
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