Glutamine-Derived Aspartate Biosynthesis in Cancer Cells: Role of Mitochondrial Transporters and New Therapeutic Perspectives

Glutamine-Derived Aspartate Biosynthesis in Cancer Cells: Role of Mitochondrial Transporters and New Therapeutic Perspectives

Aspartate has a central role in cancer cell metabolism. Aspartate cytosolic availability is crucial for protein and nucleotide biosynthesis as well as for redox homeostasis. Since tumor cells display poor aspartate uptake from the external environment, most of the cellular pool of aspartate derives...

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Bibliographic Details
Main Authors: Ruggiero Gorgoglione, Valeria Impedovo, Christopher L. Riley, Deborah Fratantonio, Stefano Tiziani, Luigi Palmieri, Vincenza Dolce, Giuseppe Fiermonte
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
cancer
glutamine metabolism
aspartate
mitochondrial carriers
UCP2
SLC1A5_var
Online Access:https://www.mdpi.com/2072-6694/14/1/245

Internet

https://www.mdpi.com/2072-6694/14/1/245

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