An overview of dengue viral infection circulating in Pakistan
Background & objectives: Dengue virus (DENV) is an RNA virus that infects approximately 2.5 billion people around the world. The incidence of dengue fever has rapidly increased at an alarming rate in the last few years and has affected thousands of people in Pakistan. This review explores the pr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Vector Borne Diseases |
| Subjects: | |
| Online Access: | http://www.jvbd.org/article.asp?issn=0972-9062;year=2022;volume=59;issue=2;spage=109;epage=114;aulast=Ali |
| _version_ | 1797995509514764288 |
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| author | Liaqat Ali Zakkia Gul Asiya Ijaz Nouman Khalid Falak Zeb Samia Afzal Anayat Ullah Fazli Subhan Saeed Ahmed |
| author_facet | Liaqat Ali Zakkia Gul Asiya Ijaz Nouman Khalid Falak Zeb Samia Afzal Anayat Ullah Fazli Subhan Saeed Ahmed |
| author_sort | Liaqat Ali |
| collection | DOAJ |
| description | Background & objectives: Dengue virus (DENV) is an RNA virus that infects approximately 2.5 billion people around the world. The incidence of dengue fever has rapidly increased at an alarming rate in the last few years and has affected thousands of people in Pakistan. This review explores the prevalence, serotypes and pathogenesis of dengue virus circulating in Pakistan.
Methods: A systematic review of observational studies published between 1994 and December 2019 was performed. All records of the confirmed outbreak of dengue fever in Pakistan were reviewed and articles containing no primary data were excluded.
Results: Four identified serotypes of dengue virus (DENV 1-4) circulate in different regions of the world causing epidemics. The most prevalent serotype, which is still epidemic and dominant in Pakistan, is DENV-2. Many factors like over-population, rapid urbanization, travelling, lack of vector control in dengue endemic areas and inadequate health-care are responsible of dynamic and huge raise of dengue in Pakistan.
Interpretation & conclusion: Currently there is no specific treatment for prevention of dengue virus. Recently some antiviral compounds were being tested to eradicate this disease. There is a need to develop an efficient and safe vaccine for all four serotypes to combat dengue viral infection globally and particularly in Pakistan. |
| first_indexed | 2024-04-11T10:02:52Z |
| format | Article |
| id | doaj.art-6598a2855c5949a7ad10621bd7c950e7 |
| institution | Directory Open Access Journal |
| issn | 0972-9062 |
| language | English |
| last_indexed | 2024-04-11T10:02:52Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Vector Borne Diseases |
| spelling | doaj.art-6598a2855c5949a7ad10621bd7c950e72022-12-22T04:30:20ZengWolters Kluwer Medknow PublicationsJournal of Vector Borne Diseases0972-90622022-01-0159210911410.4103/0972-9062.331412An overview of dengue viral infection circulating in PakistanLiaqat AliZakkia GulAsiya IjazNouman KhalidFalak ZebSamia AfzalAnayat UllahFazli SubhanSaeed AhmedBackground & objectives: Dengue virus (DENV) is an RNA virus that infects approximately 2.5 billion people around the world. The incidence of dengue fever has rapidly increased at an alarming rate in the last few years and has affected thousands of people in Pakistan. This review explores the prevalence, serotypes and pathogenesis of dengue virus circulating in Pakistan. Methods: A systematic review of observational studies published between 1994 and December 2019 was performed. All records of the confirmed outbreak of dengue fever in Pakistan were reviewed and articles containing no primary data were excluded. Results: Four identified serotypes of dengue virus (DENV 1-4) circulate in different regions of the world causing epidemics. The most prevalent serotype, which is still epidemic and dominant in Pakistan, is DENV-2. Many factors like over-population, rapid urbanization, travelling, lack of vector control in dengue endemic areas and inadequate health-care are responsible of dynamic and huge raise of dengue in Pakistan. Interpretation & conclusion: Currently there is no specific treatment for prevention of dengue virus. Recently some antiviral compounds were being tested to eradicate this disease. There is a need to develop an efficient and safe vaccine for all four serotypes to combat dengue viral infection globally and particularly in Pakistan.http://www.jvbd.org/article.asp?issn=0972-9062;year=2022;volume=59;issue=2;spage=109;epage=114;aulast=Alidengue virus; serotypes; prevalence; pathogenesis; non-structural proteins |
| spellingShingle | Liaqat Ali Zakkia Gul Asiya Ijaz Nouman Khalid Falak Zeb Samia Afzal Anayat Ullah Fazli Subhan Saeed Ahmed An overview of dengue viral infection circulating in Pakistan Journal of Vector Borne Diseases dengue virus; serotypes; prevalence; pathogenesis; non-structural proteins |
| title | An overview of dengue viral infection circulating in Pakistan |
| title_full | An overview of dengue viral infection circulating in Pakistan |
| title_fullStr | An overview of dengue viral infection circulating in Pakistan |
| title_full_unstemmed | An overview of dengue viral infection circulating in Pakistan |
| title_short | An overview of dengue viral infection circulating in Pakistan |
| title_sort | overview of dengue viral infection circulating in pakistan |
| topic | dengue virus; serotypes; prevalence; pathogenesis; non-structural proteins |
| url | http://www.jvbd.org/article.asp?issn=0972-9062;year=2022;volume=59;issue=2;spage=109;epage=114;aulast=Ali |
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