Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib in a “humanized” bone marrow-like scaffold model. For this, CFZ-PM were prepar...

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Bibliographic Details
Main Authors: Aida Varela-Moreira, Demian van Straten, Heleen F. van Leur, Ruud W.J. Ruiter, Anil K. Deshantri, Wim E. Hennink, Marcel H.A.M. Fens, Richard W.J. Groen, Raymond M. Schiffelers
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Polymeric micelles
Carfilzomib
Drug delivery
Proteasome inhibitor
Multiple Myeloma
Bone Marrow Microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156720300116

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