Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma
Abstract Earlier literature suggests that ovarian preservation in young premenopausal clinical stage I endometrioid endometrial carcinoma patients does not negatively impact prognosis. The main purpose of this study was to clarify the incidence of ovarian malignant involvement in this group and furt...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-78953-4 |
| _version_ | 1818682943947669504 |
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| author | Qin Chen Yan Feng Wenwen Wang Weiguo Lv Baohua Li |
| author_facet | Qin Chen Yan Feng Wenwen Wang Weiguo Lv Baohua Li |
| author_sort | Qin Chen |
| collection | DOAJ |
| description | Abstract Earlier literature suggests that ovarian preservation in young premenopausal clinical stage I endometrioid endometrial carcinoma patients does not negatively impact prognosis. The main purpose of this study was to clarify the incidence of ovarian malignant involvement in this group and further identify potential preoperative predictive factors of ovarian malignant involvement. A total of 511 premenopausal (age ≤ 50 years) patients were enrolled for the study at Women’s Hospital, Zhejiang University School of Medicine, between January 2002 and December 2016. Ovarian malignant involvements were detected in 23 of the patients (4.5%). Univariate and multivariate logistic analysis validated preoperative imaging of myometrial invasion depth and preoperative serum carbohydrate antigen 125 (CA125) level as independent risk predictors of postoperative ovarian malignant involvement. Receiver operating characteristic (ROC) curves was generated for a combination of the two factors. The area under curve (AUC) was 0.772 (95% confidence interval [CI] 0.661–0.884) for the combined two factors. The incidence of postoperative ovarian malignant involvement was relatively minimal. Preoperative imaging of myometrial invasion depth and serum CA125 level were independent risk predictors of ovarian malignant involvement. These findings may facilitate preoperative counseling of patients and informed clinical decision-making on ovarian preservation in these patients. |
| first_indexed | 2024-12-17T10:26:53Z |
| format | Article |
| id | doaj.art-659bd0bdb79c4c2792db7a7c8c469857 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T10:26:53Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-659bd0bdb79c4c2792db7a7c8c4698572022-12-21T21:52:37ZengNature PortfolioScientific Reports2045-23222021-01-011111810.1038/s41598-020-78953-4Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinomaQin Chen0Yan Feng1Wenwen Wang2Weiguo Lv3Baohua Li4Department of Pathology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Pathology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineAbstract Earlier literature suggests that ovarian preservation in young premenopausal clinical stage I endometrioid endometrial carcinoma patients does not negatively impact prognosis. The main purpose of this study was to clarify the incidence of ovarian malignant involvement in this group and further identify potential preoperative predictive factors of ovarian malignant involvement. A total of 511 premenopausal (age ≤ 50 years) patients were enrolled for the study at Women’s Hospital, Zhejiang University School of Medicine, between January 2002 and December 2016. Ovarian malignant involvements were detected in 23 of the patients (4.5%). Univariate and multivariate logistic analysis validated preoperative imaging of myometrial invasion depth and preoperative serum carbohydrate antigen 125 (CA125) level as independent risk predictors of postoperative ovarian malignant involvement. Receiver operating characteristic (ROC) curves was generated for a combination of the two factors. The area under curve (AUC) was 0.772 (95% confidence interval [CI] 0.661–0.884) for the combined two factors. The incidence of postoperative ovarian malignant involvement was relatively minimal. Preoperative imaging of myometrial invasion depth and serum CA125 level were independent risk predictors of ovarian malignant involvement. These findings may facilitate preoperative counseling of patients and informed clinical decision-making on ovarian preservation in these patients.https://doi.org/10.1038/s41598-020-78953-4 |
| spellingShingle | Qin Chen Yan Feng Wenwen Wang Weiguo Lv Baohua Li Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma Scientific Reports |
| title | Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma |
| title_full | Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma |
| title_fullStr | Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma |
| title_full_unstemmed | Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma |
| title_short | Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma |
| title_sort | preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage i endometrioid endometrial carcinoma |
| url | https://doi.org/10.1038/s41598-020-78953-4 |
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