Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
Abstract Our current view of DNA methylation processes is strongly moving: First, even if it was generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and DNMT1 is associated with inheritance DNA methylation, these distinctions are now not so clear. Secondly, since one de...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Clinical Epigenetics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13148-018-0450-y |
| _version_ | 1818231728793190400 |
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| author | Eric Hervouet Paul Peixoto Régis Delage-Mourroux Michaël Boyer-Guittaut Pierre-François Cartron |
| author_facet | Eric Hervouet Paul Peixoto Régis Delage-Mourroux Michaël Boyer-Guittaut Pierre-François Cartron |
| author_sort | Eric Hervouet |
| collection | DOAJ |
| description | Abstract Our current view of DNA methylation processes is strongly moving: First, even if it was generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and DNMT1 is associated with inheritance DNA methylation, these distinctions are now not so clear. Secondly, since one decade, many partners of DNMTs have been involved in both the regulation of DNA methylation activity and DNMT recruitment on DNA. The high diversity of interactions and the combination of these interactions let us to subclass the different DNMT-including complexes. For example, the DNMT3L/DNMT3A complex is mainly related to de novo DNA methylation in embryonic states, whereas the DNMT1/PCNA/UHRF1 complex is required for maintaining global DNA methylation following DNA replication. On the opposite to these unspecific DNA methylation machineries (no preferential DNA sequence), some recently identified DNMT-including complexes are recruited on specific DNA sequences. The coexistence of both types of DNA methylation (un/specific) suggests a close cooperation and an orchestration between these systems to maintain genome and epigenome integrities. Deregulation of these systems can lead to pathologic disorders. |
| first_indexed | 2024-12-12T10:55:01Z |
| format | Article |
| id | doaj.art-659bf506ec314a798b34729bce22b464 |
| institution | Directory Open Access Journal |
| issn | 1868-7075 1868-7083 |
| language | English |
| last_indexed | 2024-12-12T10:55:01Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-659bf506ec314a798b34729bce22b4642022-12-22T00:26:40ZengBMCClinical Epigenetics1868-70751868-70832018-02-0110111810.1186/s13148-018-0450-ySpecific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemmaEric Hervouet0Paul Peixoto1Régis Delage-Mourroux2Michaël Boyer-Guittaut3Pierre-François Cartron4INSERM unit 1098, University of Bourgogne Franche-ComtéINSERM unit 1098, University of Bourgogne Franche-ComtéINSERM unit 1098, University of Bourgogne Franche-ComtéINSERM unit 1098, University of Bourgogne Franche-ComtéINSERM unit S1232, University of NantesAbstract Our current view of DNA methylation processes is strongly moving: First, even if it was generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and DNMT1 is associated with inheritance DNA methylation, these distinctions are now not so clear. Secondly, since one decade, many partners of DNMTs have been involved in both the regulation of DNA methylation activity and DNMT recruitment on DNA. The high diversity of interactions and the combination of these interactions let us to subclass the different DNMT-including complexes. For example, the DNMT3L/DNMT3A complex is mainly related to de novo DNA methylation in embryonic states, whereas the DNMT1/PCNA/UHRF1 complex is required for maintaining global DNA methylation following DNA replication. On the opposite to these unspecific DNA methylation machineries (no preferential DNA sequence), some recently identified DNMT-including complexes are recruited on specific DNA sequences. The coexistence of both types of DNA methylation (un/specific) suggests a close cooperation and an orchestration between these systems to maintain genome and epigenome integrities. Deregulation of these systems can lead to pathologic disorders.http://link.springer.com/article/10.1186/s13148-018-0450-yDNA methylationDNMT1DNMT3ADNMT3BDNMT3LEpigenetics |
| spellingShingle | Eric Hervouet Paul Peixoto Régis Delage-Mourroux Michaël Boyer-Guittaut Pierre-François Cartron Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma Clinical Epigenetics DNA methylation DNMT1 DNMT3A DNMT3B DNMT3L Epigenetics |
| title | Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma |
| title_full | Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma |
| title_fullStr | Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma |
| title_full_unstemmed | Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma |
| title_short | Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma |
| title_sort | specific or not specific recruitment of dnmts for dna methylation an epigenetic dilemma |
| topic | DNA methylation DNMT1 DNMT3A DNMT3B DNMT3L Epigenetics |
| url | http://link.springer.com/article/10.1186/s13148-018-0450-y |
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