The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional study
BackgroundThe clinical features and pathological process of cerebral microbleed (CMB)-related cognitive impairment are hot topics of cerebral small vessel disease (CSVD). However, how to choose a more suitable cognitive assessment battery for CMB patients is still an urgent issue to be solved. This...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1114426/full |
| _version_ | 1797849238143500288 |
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| author | Xuanting Li Shuna Yang Yue Li Wei Qin Lei Yang Junliang Yuan Wenli Hu |
| author_facet | Xuanting Li Shuna Yang Yue Li Wei Qin Lei Yang Junliang Yuan Wenli Hu |
| author_sort | Xuanting Li |
| collection | DOAJ |
| description | BackgroundThe clinical features and pathological process of cerebral microbleed (CMB)-related cognitive impairment are hot topics of cerebral small vessel disease (CSVD). However, how to choose a more suitable cognitive assessment battery for CMB patients is still an urgent issue to be solved. This study aimed to analyze the performance of CMB patients on different cognitive tests.MethodsThis study was designed as a cross-sectional study. The five main markers of CSVD (including the CMB, white matter hyperintensities, perivascular spaces, lacunes and brain atrophy) were assessed according to magnetic resonance imaging. The burden of CMB was categorized into four grades based on the total number of lesions. Cognitive function was assessed by Mini-Mental State Examination (MMSE), Trail-Making Test (TMT, Part A and Part B), Stroop color-word test (Stroop test, Part A, B and C), Verbal Fluency Test (VF, animal), Digit-Symbol Substitution Test (DSST), Digit Cancellation Test (DCT) and Maze. Multiple linear regression analysis was conducted to analyze the association between CMB and cognitive findings.ResultsA total of 563 participants (median age of 69 years) were enrolled in this study, including 218 (38.7%) CMB patients. CMB patients showed worse performance than non-CMB subjects in each cognitive test. Correlation analysis indicated the total number of CMB lesions had positive correlations with the time of TMT, Maze and Stroop test, and negative correlations with the performance of MMSE, VF, DSST, and DCT. After the adjustment for all the potential confounders by linear regression, the CMB burden grade was correlated with the performance of VF, Stroop test C, Maze and DCT.ConclusionThe presence of CMB lesions was associated with much worse cognitive performances. In VF, Stroop test C, Maze and DCT, the correlations between CMB severity and assessment results were more significant. Our study further confirmed that the attention/executive function domain was the most commonly evaluated in CMB, which provided a picture of the most utilized tools to analyze the prognostic and diagnostic value in CMB. |
| first_indexed | 2024-04-09T18:41:44Z |
| format | Article |
| id | doaj.art-659c4f50eca2425eb14eaf6ca8e0e0ad |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-09T18:41:44Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-659c4f50eca2425eb14eaf6ca8e0e0ad2023-04-11T04:31:54ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-04-011510.3389/fnagi.2023.11144261114426The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional studyXuanting Li0Shuna Yang1Yue Li2Wei Qin3Lei Yang4Junliang Yuan5Wenli Hu6Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaBackgroundThe clinical features and pathological process of cerebral microbleed (CMB)-related cognitive impairment are hot topics of cerebral small vessel disease (CSVD). However, how to choose a more suitable cognitive assessment battery for CMB patients is still an urgent issue to be solved. This study aimed to analyze the performance of CMB patients on different cognitive tests.MethodsThis study was designed as a cross-sectional study. The five main markers of CSVD (including the CMB, white matter hyperintensities, perivascular spaces, lacunes and brain atrophy) were assessed according to magnetic resonance imaging. The burden of CMB was categorized into four grades based on the total number of lesions. Cognitive function was assessed by Mini-Mental State Examination (MMSE), Trail-Making Test (TMT, Part A and Part B), Stroop color-word test (Stroop test, Part A, B and C), Verbal Fluency Test (VF, animal), Digit-Symbol Substitution Test (DSST), Digit Cancellation Test (DCT) and Maze. Multiple linear regression analysis was conducted to analyze the association between CMB and cognitive findings.ResultsA total of 563 participants (median age of 69 years) were enrolled in this study, including 218 (38.7%) CMB patients. CMB patients showed worse performance than non-CMB subjects in each cognitive test. Correlation analysis indicated the total number of CMB lesions had positive correlations with the time of TMT, Maze and Stroop test, and negative correlations with the performance of MMSE, VF, DSST, and DCT. After the adjustment for all the potential confounders by linear regression, the CMB burden grade was correlated with the performance of VF, Stroop test C, Maze and DCT.ConclusionThe presence of CMB lesions was associated with much worse cognitive performances. In VF, Stroop test C, Maze and DCT, the correlations between CMB severity and assessment results were more significant. Our study further confirmed that the attention/executive function domain was the most commonly evaluated in CMB, which provided a picture of the most utilized tools to analyze the prognostic and diagnostic value in CMB.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1114426/fullcerebral microbleedcerebral small vessel diseasecognitive impairmentcognitive testneuroimaging |
| spellingShingle | Xuanting Li Shuna Yang Yue Li Wei Qin Lei Yang Junliang Yuan Wenli Hu The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional study Frontiers in Aging Neuroscience cerebral microbleed cerebral small vessel disease cognitive impairment cognitive test neuroimaging |
| title | The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional study |
| title_full | The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional study |
| title_fullStr | The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional study |
| title_full_unstemmed | The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional study |
| title_short | The performance of patients with cerebral microbleeds in different cognitive tests: A cross-sectional study |
| title_sort | performance of patients with cerebral microbleeds in different cognitive tests a cross sectional study |
| topic | cerebral microbleed cerebral small vessel disease cognitive impairment cognitive test neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1114426/full |
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