The Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men

The Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men

Male sex and old age are risk factors for COVID-19 severity, but the underlying causes are unknown. A possible explanation for this might be the differences in immunological profiles in males and the elderly before the infection. With this in mind, we analyzed the abundance of circulating proteins a...

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Bibliographic Details
Main Authors: Gizem Kilic, Ozlem Bulut, Martin Jaeger, Rob ter Horst, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, Vera P. Mourits, Charlotte de Bree, Jorge Domínguez-Andrés, Leo A. B. Joosten, Mihai G. Netea
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
COVID-19
aging
sex differences
seasonality
SARS-CoV-2
infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.720090/full

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