Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defects
Background: Children with ventricular septal defects (VSDs) are considered to have no difference in cardiopulmonary functional capacity with healthy children of the same age; however, studies have shown contradictory findings. The aim of this study was to assess whether Taiwanese children with VSDs...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957223000554 |
| _version_ | 1827805388761726976 |
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| author | Yen-Sen Lu Chia-Chun Chou Yu-Hsuan Tseng Ko-Long Lin Chia-Hsin Chen Yi-Jen Chen |
| author_facet | Yen-Sen Lu Chia-Chun Chou Yu-Hsuan Tseng Ko-Long Lin Chia-Hsin Chen Yi-Jen Chen |
| author_sort | Yen-Sen Lu |
| collection | DOAJ |
| description | Background: Children with ventricular septal defects (VSDs) are considered to have no difference in cardiopulmonary functional capacity with healthy children of the same age; however, studies have shown contradictory findings. The aim of this study was to assess whether Taiwanese children with VSDs exhibited cardiopulmonary deficits. Methods: This is a retrospective cohort study with the data collected from January 2010 to December 2021. All patients and controls (age-, sex-, and body mass index -matched) underwent cardiopulmonary exercise testing (CPET) and pulmonary function test. Results: In total, 157 VSD patients (80 patients with surgically closed VSDs, 77 patients with unrepaired VSDs) and 157 healthy controls were recruited. Pulmonary function test showed significant among-group differences in maximal voluntary ventilation (MVV) (p = 0.015). The surgically closed group had lower MVV compared to the control group. Regarding CPET, we found VSD patients had lower peak oxygen uptake than the controls (surgically closed group: 30.84 ± 6.27 ml/kg/min; unrepaired group: 32.00 ± 5.95 ml/kg/min; control group: 36.76 ± 6.50 ml/kg/min, p < 0.001). There was also significant among-group differences in aerobic capacity (surgically closed group: 21.20 ± 4.39 ml/kg/min; unrepaired group: 21.68 ± 4.47 ml/kg/min; control group: 26.25 ± 4.33 ml/kg/min, p < 0.001). In addition, the surgically closed group had lower heart rate average at anaerobic threshold than the control group (surgically closed group: 138.11 ± 16.42 bpm; control group: 145.78 ± 15.53 bpm, p = 0.002). Conclusion: Taiwanese children with VSD, whether surgically closed or not, have poorer cardiopulmonary performance than age-matched healthy children, and the results of the surgically closed group were even worse. |
| first_indexed | 2024-03-11T21:24:51Z |
| format | Article |
| id | doaj.art-659d41614a4d45b8921b670f3ecd0173 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-03-11T21:24:51Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-659d41614a4d45b8921b670f3ecd01732023-09-28T05:25:11ZengElsevierPediatrics and Neonatology1875-95722023-09-01645554561Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defectsYen-Sen Lu0Chia-Chun Chou1Yu-Hsuan Tseng2Ko-Long Lin3Chia-Hsin Chen4Yi-Jen Chen5Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Physical Medicine and Rehabilitation, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Physical Medicine and Rehabilitation, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, TaiwanDepartment of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Physical Medicine and Rehabilitation, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan; Corresponding author. Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.Background: Children with ventricular septal defects (VSDs) are considered to have no difference in cardiopulmonary functional capacity with healthy children of the same age; however, studies have shown contradictory findings. The aim of this study was to assess whether Taiwanese children with VSDs exhibited cardiopulmonary deficits. Methods: This is a retrospective cohort study with the data collected from January 2010 to December 2021. All patients and controls (age-, sex-, and body mass index -matched) underwent cardiopulmonary exercise testing (CPET) and pulmonary function test. Results: In total, 157 VSD patients (80 patients with surgically closed VSDs, 77 patients with unrepaired VSDs) and 157 healthy controls were recruited. Pulmonary function test showed significant among-group differences in maximal voluntary ventilation (MVV) (p = 0.015). The surgically closed group had lower MVV compared to the control group. Regarding CPET, we found VSD patients had lower peak oxygen uptake than the controls (surgically closed group: 30.84 ± 6.27 ml/kg/min; unrepaired group: 32.00 ± 5.95 ml/kg/min; control group: 36.76 ± 6.50 ml/kg/min, p < 0.001). There was also significant among-group differences in aerobic capacity (surgically closed group: 21.20 ± 4.39 ml/kg/min; unrepaired group: 21.68 ± 4.47 ml/kg/min; control group: 26.25 ± 4.33 ml/kg/min, p < 0.001). In addition, the surgically closed group had lower heart rate average at anaerobic threshold than the control group (surgically closed group: 138.11 ± 16.42 bpm; control group: 145.78 ± 15.53 bpm, p = 0.002). Conclusion: Taiwanese children with VSD, whether surgically closed or not, have poorer cardiopulmonary performance than age-matched healthy children, and the results of the surgically closed group were even worse.http://www.sciencedirect.com/science/article/pii/S1875957223000554Cardiopulmonary exercise testingCongenitalheart diseaseFunctional capacityPediatricVentricular septal defect |
| spellingShingle | Yen-Sen Lu Chia-Chun Chou Yu-Hsuan Tseng Ko-Long Lin Chia-Hsin Chen Yi-Jen Chen Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defects Pediatrics and Neonatology Cardiopulmonary exercise testing Congenitalheart disease Functional capacity Pediatric Ventricular septal defect |
| title | Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defects |
| title_full | Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defects |
| title_fullStr | Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defects |
| title_full_unstemmed | Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defects |
| title_short | Cardiopulmonary functional capacity in Taiwanese children with ventricular septal defects |
| title_sort | cardiopulmonary functional capacity in taiwanese children with ventricular septal defects |
| topic | Cardiopulmonary exercise testing Congenitalheart disease Functional capacity Pediatric Ventricular septal defect |
| url | http://www.sciencedirect.com/science/article/pii/S1875957223000554 |
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