Regulatory T cells participate in the recovery of ischemic stroke patients
Abstract Background Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, the role of Treg in human acute IS has been poorly investigated. Our aim was to study the relationship between circulating Treg and out...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-020-01648-w |
| _version_ | 1818447504528637952 |
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| author | María Santamaría-Cadavid Emilio Rodríguez-Castro Manuel Rodríguez-Yáñez Susana Arias-Rivas Iria López-Dequidt María Pérez-Mato Manuel Rodríguez-Pérez Ignacio López-Loureiro Pablo Hervella Francisco Campos José Castillo Ramón Iglesias-Rey Tomás Sobrino |
| author_facet | María Santamaría-Cadavid Emilio Rodríguez-Castro Manuel Rodríguez-Yáñez Susana Arias-Rivas Iria López-Dequidt María Pérez-Mato Manuel Rodríguez-Pérez Ignacio López-Loureiro Pablo Hervella Francisco Campos José Castillo Ramón Iglesias-Rey Tomás Sobrino |
| author_sort | María Santamaría-Cadavid |
| collection | DOAJ |
| description | Abstract Background Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, the role of Treg in human acute IS has been poorly investigated. Our aim was to study the relationship between circulating Treg and outcome in human IS patients. Methods A total of 204 IS patients and 22 control subjects were recruited. The main study variable was good functional outcome at 3 months (modified Rankin scale ≤2) considering infarct volume, Early Neurological Deterioration (END) and risk of infections as secondary variables. The percentage of circulating Treg was measured at admission, 48, 72 h and at day 7 after stroke onset. Results Circulating Treg levels were higher in IS patients compared to control subjects. Treg at 48 h were independently associated with good functional outcome (OR, 3.5; CI: 1.9–7.8) after adjusting by confounding factors. Patients with lower Treg at 48 h showed higher frequency of END and risk of infections. In addition, a negative correlation was found between circulating Treg at 48 h (r = − 0.414) and 72 h (r = − 0.418) and infarct volume. Conclusions These findings suggest that Treg may participate in the recovery of IS patients. Therefore, Treg may be considered a potential therapeutic target in acute ischemic stroke. |
| first_indexed | 2024-12-14T20:04:40Z |
| format | Article |
| id | doaj.art-65a04d6080974d9abc11a2afbb55631e |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-14T20:04:40Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-65a04d6080974d9abc11a2afbb55631e2022-12-21T22:49:04ZengBMCBMC Neurology1471-23772020-02-0120111010.1186/s12883-020-01648-wRegulatory T cells participate in the recovery of ischemic stroke patientsMaría Santamaría-Cadavid0Emilio Rodríguez-Castro1Manuel Rodríguez-Yáñez2Susana Arias-Rivas3Iria López-Dequidt4María Pérez-Mato5Manuel Rodríguez-Pérez6Ignacio López-Loureiro7Pablo Hervella8Francisco Campos9José Castillo10Ramón Iglesias-Rey11Tomás Sobrino12Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS)Abstract Background Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, the role of Treg in human acute IS has been poorly investigated. Our aim was to study the relationship between circulating Treg and outcome in human IS patients. Methods A total of 204 IS patients and 22 control subjects were recruited. The main study variable was good functional outcome at 3 months (modified Rankin scale ≤2) considering infarct volume, Early Neurological Deterioration (END) and risk of infections as secondary variables. The percentage of circulating Treg was measured at admission, 48, 72 h and at day 7 after stroke onset. Results Circulating Treg levels were higher in IS patients compared to control subjects. Treg at 48 h were independently associated with good functional outcome (OR, 3.5; CI: 1.9–7.8) after adjusting by confounding factors. Patients with lower Treg at 48 h showed higher frequency of END and risk of infections. In addition, a negative correlation was found between circulating Treg at 48 h (r = − 0.414) and 72 h (r = − 0.418) and infarct volume. Conclusions These findings suggest that Treg may participate in the recovery of IS patients. Therefore, Treg may be considered a potential therapeutic target in acute ischemic stroke.http://link.springer.com/article/10.1186/s12883-020-01648-wEarly neurological deteriorationInterleukin-10Ischemic strokeNeuroinflammationRegulatory T cellsRisk factors |
| spellingShingle | María Santamaría-Cadavid Emilio Rodríguez-Castro Manuel Rodríguez-Yáñez Susana Arias-Rivas Iria López-Dequidt María Pérez-Mato Manuel Rodríguez-Pérez Ignacio López-Loureiro Pablo Hervella Francisco Campos José Castillo Ramón Iglesias-Rey Tomás Sobrino Regulatory T cells participate in the recovery of ischemic stroke patients BMC Neurology Early neurological deterioration Interleukin-10 Ischemic stroke Neuroinflammation Regulatory T cells Risk factors |
| title | Regulatory T cells participate in the recovery of ischemic stroke patients |
| title_full | Regulatory T cells participate in the recovery of ischemic stroke patients |
| title_fullStr | Regulatory T cells participate in the recovery of ischemic stroke patients |
| title_full_unstemmed | Regulatory T cells participate in the recovery of ischemic stroke patients |
| title_short | Regulatory T cells participate in the recovery of ischemic stroke patients |
| title_sort | regulatory t cells participate in the recovery of ischemic stroke patients |
| topic | Early neurological deterioration Interleukin-10 Ischemic stroke Neuroinflammation Regulatory T cells Risk factors |
| url | http://link.springer.com/article/10.1186/s12883-020-01648-w |
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