Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits
In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory functi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00358/full |
| _version_ | 1818603206015451136 |
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| author | Nicholas D. James Maria Angéria Elizabeth J. Bradbury Peter Damberg Stephen B. McMahon Mårten Risling Thomas Carlstedt |
| author_facet | Nicholas D. James Maria Angéria Elizabeth J. Bradbury Peter Damberg Stephen B. McMahon Mårten Risling Thomas Carlstedt |
| author_sort | Nicholas D. James |
| collection | DOAJ |
| description | In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory function. The dorsal root ganglia (DRG) containing the primary sensory nerve cells had been surgically removed in order for secondary or spinal cord sensory neurons to extend into the periphery and replace the deleted DRG neurons. The present experimental study uses a rat injury model first to corroborate the clinical finding of a re-established spinal reflex arch, and second, to elucidate some of the potential mechanisms underlying these findings by means of morphological, immunohistochemical, and electrophysiological assessments. Our findings indicate that, after spinal cord surgery, the central nervous system sensory system could replace the traumatically detached original peripheral sensory connections through new neurite growth from dendrites. |
| first_indexed | 2024-12-16T13:19:29Z |
| format | Article |
| id | doaj.art-65a059fe662e465d9cb2cf73e8ff20dc |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T13:19:29Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-65a059fe662e465d9cb2cf73e8ff20dc2022-12-21T22:30:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-07-01810.3389/fneur.2017.00358265629Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord CircuitsNicholas D. James0Maria Angéria1Elizabeth J. Bradbury2Peter Damberg3Stephen B. McMahon4Mårten Risling5Thomas Carlstedt6The Wolfson Centre for Age-Related Diseases, King’s College London, London, United KingdomDepartment of Neuroscience, Karolinska Institutet, Solna, SwedenThe Wolfson Centre for Age-Related Diseases, King’s College London, London, United KingdomDepartment of Clinical Neuroscience, Karolinska Institutet, Solna, SwedenThe Wolfson Centre for Age-Related Diseases, King’s College London, London, United KingdomDepartment of Neuroscience, Karolinska Institutet, Solna, SwedenThe Wolfson Centre for Age-Related Diseases, King’s College London, London, United KingdomIn a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory function. The dorsal root ganglia (DRG) containing the primary sensory nerve cells had been surgically removed in order for secondary or spinal cord sensory neurons to extend into the periphery and replace the deleted DRG neurons. The present experimental study uses a rat injury model first to corroborate the clinical finding of a re-established spinal reflex arch, and second, to elucidate some of the potential mechanisms underlying these findings by means of morphological, immunohistochemical, and electrophysiological assessments. Our findings indicate that, after spinal cord surgery, the central nervous system sensory system could replace the traumatically detached original peripheral sensory connections through new neurite growth from dendrites.http://journal.frontiersin.org/article/10.3389/fneur.2017.00358/fullavulsion injurysensory neuronsplasticityproprioceptionelectrophysiology |
| spellingShingle | Nicholas D. James Maria Angéria Elizabeth J. Bradbury Peter Damberg Stephen B. McMahon Mårten Risling Thomas Carlstedt Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits Frontiers in Neurology avulsion injury sensory neurons plasticity proprioception electrophysiology |
| title | Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits |
| title_full | Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits |
| title_fullStr | Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits |
| title_full_unstemmed | Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits |
| title_short | Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits |
| title_sort | structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells an alternative concept in reconstruction of spinal cord circuits |
| topic | avulsion injury sensory neurons plasticity proprioception electrophysiology |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00358/full |
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