Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors
A series of anionic homopolymers, poly(sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and amphiphilic copolymers of AMPS and sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS<sub>75</sub>-b-PAaU<sub>n</sub>), and random (P(AMPS<sub>m</sub>-co-...
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| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/2/309 |
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| author | Pawel Botwina Magdalena Obłoza Maria Zatorska-Płachta Kamil Kamiński Masanobu Mizusaki Shin-Ichi Yusa Krzysztof Szczubiałka Krzysztof Pyrc Maria Nowakowska |
| author_facet | Pawel Botwina Magdalena Obłoza Maria Zatorska-Płachta Kamil Kamiński Masanobu Mizusaki Shin-Ichi Yusa Krzysztof Szczubiałka Krzysztof Pyrc Maria Nowakowska |
| author_sort | Pawel Botwina |
| collection | DOAJ |
| description | A series of anionic homopolymers, poly(sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and amphiphilic copolymers of AMPS and sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS<sub>75</sub>-b-PAaU<sub>n</sub>), and random (P(AMPS<sub>m</sub>-co-AaU<sub>n</sub>)), were synthesized and their antiviral activity against Zika virus (ZIKV) was evaluated. Interestingly, while the homopolymers showed limited antiviral activity, the copolymers are very efficient antivirals. This observation was explained considering that under the conditions relevant to the biological experiments (pH 7.4 PBS buffer) the macromolecules of these copolymers exist as negatively charged (zeta potential about −25 mV) nanoparticles (4–12 nm) due to their self-organization. They inhibit the ZIKV replication cycle by binding to the cell surface and thereby blocking virus attachment to host cells. Considering good solubility in aqueous media, low toxicity, and high selectivity index (SI) of the PAMPS-b-PAaU copolymers, they can be considered promising agents against ZIKV infections. |
| first_indexed | 2024-03-09T21:14:57Z |
| format | Article |
| id | doaj.art-65a1ea859f8943bbbacf4be3e91e8aa9 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:14:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-65a1ea859f8943bbbacf4be3e91e8aa92023-11-23T21:37:09ZengMDPI AGPharmaceutics1999-49232022-01-0114230910.3390/pharmaceutics14020309Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus InhibitorsPawel Botwina0Magdalena Obłoza1Maria Zatorska-Płachta2Kamil Kamiński3Masanobu Mizusaki4Shin-Ichi Yusa5Krzysztof Szczubiałka6Krzysztof Pyrc7Maria Nowakowska8Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, PolandDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, PolandDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, PolandDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, PolandDepartment of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji 671-2280, JapanDepartment of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji 671-2280, JapanDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, PolandVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Krakow, PolandDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, PolandA series of anionic homopolymers, poly(sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and amphiphilic copolymers of AMPS and sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS<sub>75</sub>-b-PAaU<sub>n</sub>), and random (P(AMPS<sub>m</sub>-co-AaU<sub>n</sub>)), were synthesized and their antiviral activity against Zika virus (ZIKV) was evaluated. Interestingly, while the homopolymers showed limited antiviral activity, the copolymers are very efficient antivirals. This observation was explained considering that under the conditions relevant to the biological experiments (pH 7.4 PBS buffer) the macromolecules of these copolymers exist as negatively charged (zeta potential about −25 mV) nanoparticles (4–12 nm) due to their self-organization. They inhibit the ZIKV replication cycle by binding to the cell surface and thereby blocking virus attachment to host cells. Considering good solubility in aqueous media, low toxicity, and high selectivity index (SI) of the PAMPS-b-PAaU copolymers, they can be considered promising agents against ZIKV infections.https://www.mdpi.com/1999-4923/14/2/309Zika virussodium 2-(acrylamido)-2-methyl-1-propanesulfonatesodium 11-(acrylamido)undecanoateamphiphilic copolymers |
| spellingShingle | Pawel Botwina Magdalena Obłoza Maria Zatorska-Płachta Kamil Kamiński Masanobu Mizusaki Shin-Ichi Yusa Krzysztof Szczubiałka Krzysztof Pyrc Maria Nowakowska Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors Pharmaceutics Zika virus sodium 2-(acrylamido)-2-methyl-1-propanesulfonate sodium 11-(acrylamido)undecanoate amphiphilic copolymers |
| title | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
| title_full | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
| title_fullStr | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
| title_full_unstemmed | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
| title_short | Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors |
| title_sort | self organized nanoparticles of random and block copolymers of sodium 2 acrylamido 2 methyl 1 propanesulfonate and sodium 11 acrylamido undecanoate as safe and effective zika virus inhibitors |
| topic | Zika virus sodium 2-(acrylamido)-2-methyl-1-propanesulfonate sodium 11-(acrylamido)undecanoate amphiphilic copolymers |
| url | https://www.mdpi.com/1999-4923/14/2/309 |
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