The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes
ContextDiabetic retinopathy (DR) and diabetic nephropathy (DN), are major microvascular complications of diabetes. DR is an important predictor of DN, but the relationship between the severity of DR and the pathological severity of diabetic glomerulopathy remains unclear.ObjectiveTo investigate the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1292412/full |
| _version_ | 1797346090602725376 |
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| author | Qian Wang Haimei Cheng Shuangshuang Jiang Li Zhang Xiaomin Liu Pu Chen Jiaona Liu Ying Li Xiaocui Liu Liqiang Wang Zhaohui Li Guangyan Cai Xiangmei Chen Zheyi Dong |
| author_facet | Qian Wang Haimei Cheng Shuangshuang Jiang Li Zhang Xiaomin Liu Pu Chen Jiaona Liu Ying Li Xiaocui Liu Liqiang Wang Zhaohui Li Guangyan Cai Xiangmei Chen Zheyi Dong |
| author_sort | Qian Wang |
| collection | DOAJ |
| description | ContextDiabetic retinopathy (DR) and diabetic nephropathy (DN), are major microvascular complications of diabetes. DR is an important predictor of DN, but the relationship between the severity of DR and the pathological severity of diabetic glomerulopathy remains unclear.ObjectiveTo investigate the relationship between severity of diabetic retinopathy (DR) and histological changes and clinical indicators of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM)MethodsPatients with T2DM (n=272) who underwent a renal biopsy were eligible. Severity of DR was classified as non-diabetic retinopathy, non-proliferative retinopathy, and proliferative retinopathy (PDR). Relationship between DN and DR and the diagnostic efficacy of DR for DN were explored.ResultsDN had a higher prevalence of DR (86.4%) and DR was more severe. The sensitivity and specificity of DR in DN were 86.4% and 78.8%, while PDR was 26.4% and 98.5%, respectively. In DN patients, the severity of glomerular lesions (p=0.001) and prevalence of KW nodules (p<0.001) significantly increased with increasing severity of DR. The presence of KW nodules, lower hemoglobin levels, and younger age were independent risk factors associated with more severe DR in patients with DN.ConclusionDR was a good predictor of DN. In DN patients, the severity of DR was associated with glomerular injury, and presence of KW nodules, lower hemoglobin levels and younger age were independent risk factors associated with more severe DR.Trial registrationClinicalTrails.gov, NCT03865914. |
| first_indexed | 2024-03-08T11:27:50Z |
| format | Article |
| id | doaj.art-65a238b434494b80a4284f2837a7abd3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T11:27:50Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-65a238b434494b80a4284f2837a7abd32024-01-26T04:49:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011510.3389/fendo.2024.12924121292412The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetesQian Wang0Haimei Cheng1Shuangshuang Jiang2Li Zhang3Xiaomin Liu4Pu Chen5Jiaona Liu6Ying Li7Xiaocui Liu8Liqiang Wang9Zhaohui Li10Guangyan Cai11Xiangmei Chen12Zheyi Dong13Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaSenior Department of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, ChinaSenior Department of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, ChinaSenior Department of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, ChinaSenior Department of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaContextDiabetic retinopathy (DR) and diabetic nephropathy (DN), are major microvascular complications of diabetes. DR is an important predictor of DN, but the relationship between the severity of DR and the pathological severity of diabetic glomerulopathy remains unclear.ObjectiveTo investigate the relationship between severity of diabetic retinopathy (DR) and histological changes and clinical indicators of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM)MethodsPatients with T2DM (n=272) who underwent a renal biopsy were eligible. Severity of DR was classified as non-diabetic retinopathy, non-proliferative retinopathy, and proliferative retinopathy (PDR). Relationship between DN and DR and the diagnostic efficacy of DR for DN were explored.ResultsDN had a higher prevalence of DR (86.4%) and DR was more severe. The sensitivity and specificity of DR in DN were 86.4% and 78.8%, while PDR was 26.4% and 98.5%, respectively. In DN patients, the severity of glomerular lesions (p=0.001) and prevalence of KW nodules (p<0.001) significantly increased with increasing severity of DR. The presence of KW nodules, lower hemoglobin levels, and younger age were independent risk factors associated with more severe DR in patients with DN.ConclusionDR was a good predictor of DN. In DN patients, the severity of DR was associated with glomerular injury, and presence of KW nodules, lower hemoglobin levels and younger age were independent risk factors associated with more severe DR.Trial registrationClinicalTrails.gov, NCT03865914.https://www.frontiersin.org/articles/10.3389/fendo.2024.1292412/fulldiabetic nephropathynon-diabetic renal diseasediabetic retinopathydiabetes mellitusKW nodules |
| spellingShingle | Qian Wang Haimei Cheng Shuangshuang Jiang Li Zhang Xiaomin Liu Pu Chen Jiaona Liu Ying Li Xiaocui Liu Liqiang Wang Zhaohui Li Guangyan Cai Xiangmei Chen Zheyi Dong The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes Frontiers in Endocrinology diabetic nephropathy non-diabetic renal disease diabetic retinopathy diabetes mellitus KW nodules |
| title | The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes |
| title_full | The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes |
| title_fullStr | The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes |
| title_full_unstemmed | The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes |
| title_short | The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes |
| title_sort | relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes |
| topic | diabetic nephropathy non-diabetic renal disease diabetic retinopathy diabetes mellitus KW nodules |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1292412/full |
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