Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds
Deuteration of unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds is a simple route to deuterated compounds, of use in pharmaceutical chemistry, material science, and synthetic chemistry. Here, the authors describe a hydrogen/deuterium (H/D) exchange of remote unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds via photocatalysis,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31956-3 |
| _version_ | 1817968808066809856 |
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| author | Nian Li Jinhang Li Mingzhe Qin Jiajun Li Jie Han Chengjian Zhu Weipeng Li Jin Xie |
| author_facet | Nian Li Jinhang Li Mingzhe Qin Jiajun Li Jie Han Chengjian Zhu Weipeng Li Jin Xie |
| author_sort | Nian Li |
| collection | DOAJ |
| description | Deuteration of unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds is a simple route to deuterated compounds, of use in pharmaceutical chemistry, material science, and synthetic chemistry. Here, the authors describe a hydrogen/deuterium (H/D) exchange of remote unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds via photocatalysis, proceeding through hydrogen atom transfer. |
| first_indexed | 2024-04-13T20:13:40Z |
| format | Article |
| id | doaj.art-65a43c9c4b6b4e0cb4d4ef2da9785eeb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T20:13:40Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-65a43c9c4b6b4e0cb4d4ef2da9785eeb2022-12-22T02:31:46ZengNature PortfolioNature Communications2041-17232022-07-011311810.1038/s41467-022-31956-3Highly selective single and multiple deuteration of unactivated C(sp3)-H bondsNian Li0Jinhang Li1Mingzhe Qin2Jiajun Li3Jie Han4Chengjian Zhu5Weipeng Li6Jin Xie7State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityDeuteration of unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds is a simple route to deuterated compounds, of use in pharmaceutical chemistry, material science, and synthetic chemistry. Here, the authors describe a hydrogen/deuterium (H/D) exchange of remote unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds via photocatalysis, proceeding through hydrogen atom transfer.https://doi.org/10.1038/s41467-022-31956-3 |
| spellingShingle | Nian Li Jinhang Li Mingzhe Qin Jiajun Li Jie Han Chengjian Zhu Weipeng Li Jin Xie Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds Nature Communications |
| title | Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds |
| title_full | Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds |
| title_fullStr | Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds |
| title_full_unstemmed | Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds |
| title_short | Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds |
| title_sort | highly selective single and multiple deuteration of unactivated c sp3 h bonds |
| url | https://doi.org/10.1038/s41467-022-31956-3 |
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