Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
The human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600018&lng=en&tlng=en |
| _version_ | 1797713349789614080 |
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| author | Klaysa Moreira-Ramos Flávia Madeira Monteiro de Castro Leandra Linhares-Lacerda Wilson Savino |
| author_facet | Klaysa Moreira-Ramos Flávia Madeira Monteiro de Castro Leandra Linhares-Lacerda Wilson Savino |
| author_sort | Klaysa Moreira-Ramos |
| collection | DOAJ |
| description | The human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1+-infected T cells and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed in TECs. After incubating TECs with culture supernatants from HTLV-1+-infected T cells, we detected gp46 on TEC membranes and the HTLV-1 tax gene integrated in the TEC genome. In conclusion, the human thymic epithelium can be infected in vitro by HTLV-1, not only via cell-cell contact, but also via exposure to virus-containing medium. |
| first_indexed | 2024-03-12T07:34:08Z |
| format | Article |
| id | doaj.art-65a5c1f3ce284629b9a76afed80d3852 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:34:08Z |
| publishDate | 2011-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-65a5c1f3ce284629b9a76afed80d38522023-09-02T21:33:23ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-09-01106675976210.1590/S0074-02762011000600018S0074-02762011000600018Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?Klaysa Moreira-Ramos0Flávia Madeira Monteiro de Castro1Leandra Linhares-Lacerda2Wilson Savino3Fundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzThe human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1+-infected T cells and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed in TECs. After incubating TECs with culture supernatants from HTLV-1+-infected T cells, we detected gp46 on TEC membranes and the HTLV-1 tax gene integrated in the TEC genome. In conclusion, the human thymic epithelium can be infected in vitro by HTLV-1, not only via cell-cell contact, but also via exposure to virus-containing medium.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600018&lng=en&tlng=enthymic epithelial cellsHTLV-1 infectionadult T cell leukaemiacell adhesion |
| spellingShingle | Klaysa Moreira-Ramos Flávia Madeira Monteiro de Castro Leandra Linhares-Lacerda Wilson Savino Can thymic epithelial cells be infected by human T-lymphotropic virus type 1? Memorias do Instituto Oswaldo Cruz thymic epithelial cells HTLV-1 infection adult T cell leukaemia cell adhesion |
| title | Can thymic epithelial cells be infected by human T-lymphotropic virus type 1? |
| title_full | Can thymic epithelial cells be infected by human T-lymphotropic virus type 1? |
| title_fullStr | Can thymic epithelial cells be infected by human T-lymphotropic virus type 1? |
| title_full_unstemmed | Can thymic epithelial cells be infected by human T-lymphotropic virus type 1? |
| title_short | Can thymic epithelial cells be infected by human T-lymphotropic virus type 1? |
| title_sort | can thymic epithelial cells be infected by human t lymphotropic virus type 1 |
| topic | thymic epithelial cells HTLV-1 infection adult T cell leukaemia cell adhesion |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600018&lng=en&tlng=en |
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