Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male rats
Background: Cucumis sativus (cucumber) is regarded as a healthy fruit because of the beneficial effects of its phytochemical constituents. However, there is a deficit of information about its effect on male reproductive physiology. Objective: This study was conducted to investigate the effect of aqu...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | International Journal of Medicine and Health Development |
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| Online Access: | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2023;volume=28;issue=2;spage=114;epage=118;aulast= |
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| author | Olawale O Obembe Taiwo A Abayomi Olorunfemi S Tokunbo Joseph B Dare Taofeek O Usman |
| author_facet | Olawale O Obembe Taiwo A Abayomi Olorunfemi S Tokunbo Joseph B Dare Taofeek O Usman |
| author_sort | Olawale O Obembe |
| collection | DOAJ |
| description | Background: Cucumis sativus (cucumber) is regarded as a healthy fruit because of the beneficial effects of its phytochemical constituents. However, there is a deficit of information about its effect on male reproductive physiology. Objective: This study was conducted to investigate the effect of aqueous extract of C. sativus (AECS) on male reproductive hormones, oxidative stress biomarkers, and lipid profile. Materials and Methods: Ten male rats were randomly assigned into two (control and treated) groups (n = 5). In the treated group, a single dose of AECS (500 mg/kg) was administered daily for 6 weeks and thereafter sacrificed under sodium pentobarbital anesthesia. Blood was collected and analyzed for sex hormones, antioxidants, and lipid profile markers. The testicular homogenate was also analyzed for antioxidants. Results: The AECS increased (P < 0.05) serum testosterone and luteinizing hormone levels (4.43 ± 0.34 and 7.50 ± 1.31, respectively) when compared with the control. Also, testicular catalase and serum level of high-density lipoprotein were increased (27.45 ± 0.19 and 30.08 ± 5.22, respectively) (P < 0.05), whereas serum low-density lipoprotein decreased (72.79 ± 9.56) (P < 0.05) in the extract treated rats. However, serum antioxidant levels were not affected. Conclusions: AECS is beneficial to male reproductive physiology evidenced by improved lipid profile and hormonal indices. Also, the integrity of the testicular redox profile was well maintained. |
| first_indexed | 2024-03-13T10:35:00Z |
| format | Article |
| id | doaj.art-65a81b89f24f4e6eae5401ff92c2e61a |
| institution | Directory Open Access Journal |
| issn | 2635-3695 |
| language | English |
| last_indexed | 2024-03-13T10:35:00Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Medicine and Health Development |
| spelling | doaj.art-65a81b89f24f4e6eae5401ff92c2e61a2023-05-18T06:21:19ZengWolters Kluwer Medknow PublicationsInternational Journal of Medicine and Health Development2635-36952023-01-0128211411810.4103/ijmh.IJMH_45_22Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male ratsOlawale O ObembeTaiwo A AbayomiOlorunfemi S TokunboJoseph B DareTaofeek O UsmanBackground: Cucumis sativus (cucumber) is regarded as a healthy fruit because of the beneficial effects of its phytochemical constituents. However, there is a deficit of information about its effect on male reproductive physiology. Objective: This study was conducted to investigate the effect of aqueous extract of C. sativus (AECS) on male reproductive hormones, oxidative stress biomarkers, and lipid profile. Materials and Methods: Ten male rats were randomly assigned into two (control and treated) groups (n = 5). In the treated group, a single dose of AECS (500 mg/kg) was administered daily for 6 weeks and thereafter sacrificed under sodium pentobarbital anesthesia. Blood was collected and analyzed for sex hormones, antioxidants, and lipid profile markers. The testicular homogenate was also analyzed for antioxidants. Results: The AECS increased (P < 0.05) serum testosterone and luteinizing hormone levels (4.43 ± 0.34 and 7.50 ± 1.31, respectively) when compared with the control. Also, testicular catalase and serum level of high-density lipoprotein were increased (27.45 ± 0.19 and 30.08 ± 5.22, respectively) (P < 0.05), whereas serum low-density lipoprotein decreased (72.79 ± 9.56) (P < 0.05) in the extract treated rats. However, serum antioxidant levels were not affected. Conclusions: AECS is beneficial to male reproductive physiology evidenced by improved lipid profile and hormonal indices. Also, the integrity of the testicular redox profile was well maintained.http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2023;volume=28;issue=2;spage=114;epage=118;aulast=antioxidantscucumbercucumis sativuslipid profilesex hormones |
| spellingShingle | Olawale O Obembe Taiwo A Abayomi Olorunfemi S Tokunbo Joseph B Dare Taofeek O Usman Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male rats International Journal of Medicine and Health Development antioxidants cucumber cucumis sativus lipid profile sex hormones |
| title | Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male rats |
| title_full | Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male rats |
| title_fullStr | Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male rats |
| title_full_unstemmed | Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male rats |
| title_short | Sex hormones, antioxidants and lipid profile of aqueous Cucumis sativus L. (cucumber) treated male rats |
| title_sort | sex hormones antioxidants and lipid profile of aqueous cucumis sativus l cucumber treated male rats |
| topic | antioxidants cucumber cucumis sativus lipid profile sex hormones |
| url | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2023;volume=28;issue=2;spage=114;epage=118;aulast= |
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