Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense
Mycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | New Microbes and New Infections |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S205229751630097X |
| _version_ | 1828444191090278400 |
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| author | M.N. Gonzalez-Perez M.I. Murcia C. Parra-Lopez J. Blom A. Tauch |
| author_facet | M.N. Gonzalez-Perez M.I. Murcia C. Parra-Lopez J. Blom A. Tauch |
| author_sort | M.N. Gonzalez-Perez |
| collection | DOAJ |
| description | Mycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. In this study we provided immunologic and virulence-related insights into the M. colombiense genome as a model of an opportunistic pathogen in the MAC. By using bioinformatic tools we found that M. colombiense has deletions in the genes involved in p-HBA/PDIM/PGL, PLC, SL-1 and HspX production, and loss of the ESX-1 locus. This information not only sheds light on our understanding the virulence mechanisms used by opportunistic MAC pathogens but also has great potential for the designing of species-specific diagnostic tools. |
| first_indexed | 2024-12-10T21:39:44Z |
| format | Article |
| id | doaj.art-65aa53a6e40c401294bec06845eb8ea4 |
| institution | Directory Open Access Journal |
| issn | 2052-2975 |
| language | English |
| last_indexed | 2024-12-10T21:39:44Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj.art-65aa53a6e40c401294bec06845eb8ea42022-12-22T01:32:32ZengElsevierNew Microbes and New Infections2052-29752016-11-0114C9810510.1016/j.nmni.2016.09.007Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombienseM.N. Gonzalez-Perez0M.I. Murcia1C. Parra-Lopez2J. Blom3A. Tauch4Microbiology Department, School of Medicine, National University of Colombia, Bogotá, ColombiaMicrobiology Department, School of Medicine, National University of Colombia, Bogotá, ColombiaMicrobiology Department, School of Medicine, National University of Colombia, Bogotá, ColombiaBioinformatics and Systems Biology, Justus Liebig University Giessen, Giessen, GermanyMicrobiology Department, School of Medicine, National University of Colombia, Bogotá, ColombiaMycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. In this study we provided immunologic and virulence-related insights into the M. colombiense genome as a model of an opportunistic pathogen in the MAC. By using bioinformatic tools we found that M. colombiense has deletions in the genes involved in p-HBA/PDIM/PGL, PLC, SL-1 and HspX production, and loss of the ESX-1 locus. This information not only sheds light on our understanding the virulence mechanisms used by opportunistic MAC pathogens but also has great potential for the designing of species-specific diagnostic tools.http://www.sciencedirect.com/science/article/pii/S205229751630097XGenomic islandsMycobacterium colombiensenontuberculous mycobacteriatuberculosisvirulence factors |
| spellingShingle | M.N. Gonzalez-Perez M.I. Murcia C. Parra-Lopez J. Blom A. Tauch Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense New Microbes and New Infections Genomic islands Mycobacterium colombiense nontuberculous mycobacteria tuberculosis virulence factors |
| title | Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense |
| title_full | Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense |
| title_fullStr | Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense |
| title_full_unstemmed | Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense |
| title_short | Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense |
| title_sort | deciphering the virulence factors of the opportunistic pathogen mycobacterium colombiense |
| topic | Genomic islands Mycobacterium colombiense nontuberculous mycobacteria tuberculosis virulence factors |
| url | http://www.sciencedirect.com/science/article/pii/S205229751630097X |
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